GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis
about
Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members.GSK-3: Functional Insights from Cell Biology and Animal Models.C-Src-mediated phosphorylation of δ-catenin increases its protein stability and the ability of inducing nuclear distribution of β-catenin.Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCATEstrogen receptor beta signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein.δ-Catenin, a Wnt/β-catenin modulator, reveals inducible mutagenesis promoting cancer cell survival adaptation and metabolic reprogramming.δ-Catenin dysregulation in cancer: interactions with E-cadherin and beyond.What Are the bona fide GSK3 Substrates?TNFα-mediated loss of β-catenin/E-cadherin association and subsequent increase in cell migration is partially restored by NKX3.1 expression in prostate cellsDown's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathwayBeyond β-catenin: prospects for a larger catenin network in the nucleusδ-Catenin promotes E-cadherin processing and activates β-catenin-mediated signaling: implications on human prostate cancer progression.Beta-catenin versus the other armadillo catenins: assessing our current view of canonical Wnt signaling.Glycogen Synthase Kinase 3 (GSK-3)-mediated Phosphorylation of Uracil N-Glycosylase 2 (UNG2) Facilitates the Repair of Floxuridine-induced DNA Lesions and Promotes Cell Survival.Genetic alterations of δ-catenin/NPRAP/Neurojungin (CTNND2): functional implications in complex human diseases.δ-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.δ-Catenin overexpression promotes angiogenic potential of CWR22Rv-1 prostate cancer cells via HIF-1α and VEGF.Functional roles of p120ctn family of proteins in central neurons.PI3K mediated activation of GSK-3β reduces at-level primary afferent growth responses associated with excitotoxic spinal cord injury dysesthesiasA partnership with the proteasome; the destructive nature of GSK3.Lithium increases synaptic GluA2 in hippocampal neurons by elevating the δ-catenin protein.Frequently rearranged and overexpressed δ-catenin is responsible for low sensitivity of prostate cancer cells to androgen receptor and β-catenin antagonists.
P2860
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P2860
GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
GSK-3 phosphorylates delta-cat ...... roteosome-mediated proteolysis
@ast
GSK-3 phosphorylates delta-cat ...... roteosome-mediated proteolysis
@en
GSK-3 phosphorylates delta-cat ...... roteosome-mediated proteolysis
@en-gb
GSK-3 phosphorylates delta-cat ...... roteosome-mediated proteolysis
@nl
type
label
GSK-3 phosphorylates delta-cat ...... roteosome-mediated proteolysis
@ast
GSK-3 phosphorylates delta-cat ...... roteosome-mediated proteolysis
@en
GSK-3 phosphorylates delta-cat ...... roteosome-mediated proteolysis
@en-gb
GSK-3 phosphorylates delta-cat ...... roteosome-mediated proteolysis
@nl
prefLabel
GSK-3 phosphorylates delta-cat ...... roteosome-mediated proteolysis
@ast
GSK-3 phosphorylates delta-cat ...... roteosome-mediated proteolysis
@en
GSK-3 phosphorylates delta-cat ...... roteosome-mediated proteolysis
@en-gb
GSK-3 phosphorylates delta-cat ...... roteosome-mediated proteolysis
@nl
P2093
P2860
P921
P356
P1476
GSK-3 phosphorylates delta-cat ...... roteosome-mediated proteolysis
@en
P2093
Hangun Kim
Hyunkyoung Ki
Ilhwan Yang
Ja-Hye Park
Jinhyung No
Jung-Kap Choi
Kwonseop Kim
Moon-Chang Baek
P2860
P304
P356
10.1074/JBC.M109.002659
P407
P577
2009-10-16T00:00:00Z