A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.
about
Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signalingGSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysisCD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide productionPTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid raftsWnt/beta-catenin signaling and small molecule inhibitorsIntercellular adhesion molecules (ICAMs) and spermatogenesisCancer cells cut homophilic cell adhesion molecules and runThe Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretaseA core function for p120-catenin in cadherin turnoverA novel role for p120 catenin in E-cadherin functionA novel mechanism for the regulation of amyloid precursor protein metabolismConditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegenerationGuidance of Signaling Activations by Cadherins and Integrins in Epithelial Ovarian Cancer CellsMitochondria-associated ER membranes and Alzheimer diseaseAdherens junction turnover: regulating adhesion through cadherin endocytosis, degradation, and recyclingCellular mechanisms of γ-secretase substrate selection, processing and toxicityE-cadherin's dark side: possible role in tumor progressionTargeting γ-secretase in breast cancerSynaptic circuit remodelling by matrix metalloproteinases in health and diseaseAlzheimer's-related peptide amyloid-β plays a conserved role in angiogenesisCRIM1 complexes with ß-catenin and cadherins, stabilizes cell-cell junctions and is critical for neural morphogenesisStepwise Evolution of Coral Biomineralization Revealed with Genome-Wide Proteomics and TranscriptomicsE-cadherin roles in animal biology: A perspective on thyroid hormone-influenceDynamic self-guiding analysis of Alzheimer's disease.Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptorThe Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragmentsProcessing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcriptionCoordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivationPresenilin/gamma-secretase and alpha-secretase-like peptidases cleave human MHC Class I proteinsCombinatorial expression of alpha- and gamma-protocadherins alters their presenilin-dependent processingMechanism and biological significance of CD44 cleavageNovel processed form of syndecan-1 shed from SCC-9 cells plays a role in cell migration.Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC)PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutationsPresenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnoverEpithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma: Characterization in a 3D-cell culture modelTGF-beta and epithelial-to-mesenchymal transitionsConvergence of Wnt, beta-catenin, and cadherin pathwaysNotch inhibitors as a new tool in the war on cancer: a pathway to watch.
P2860
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P248
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P2860
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
A presenilin-1/gamma-secretase ...... assembly of adherens junctions
@nl
A presenilin-1/gamma-secretase ...... ssembly of adherens junctions.
@ast
A presenilin-1/gamma-secretase ...... ssembly of adherens junctions.
@en
A presenilin-1/gamma-secretase ...... ssembly of adherens junctions.
@en-gb
type
label
A presenilin-1/gamma-secretase ...... assembly of adherens junctions
@nl
A presenilin-1/gamma-secretase ...... ssembly of adherens junctions.
@ast
A presenilin-1/gamma-secretase ...... ssembly of adherens junctions.
@en
A presenilin-1/gamma-secretase ...... ssembly of adherens junctions.
@en-gb
prefLabel
A presenilin-1/gamma-secretase ...... assembly of adherens junctions
@nl
A presenilin-1/gamma-secretase ...... ssembly of adherens junctions.
@ast
A presenilin-1/gamma-secretase ...... ssembly of adherens junctions.
@en
A presenilin-1/gamma-secretase ...... ssembly of adherens junctions.
@en-gb
P2093
P2860
P921
P3181
P356
P1433
P1476
A presenilin-1/gamma-secretase ...... ssembly of adherens junctions.
@en
P2093
Anastasios Georgakopoulos
Geo Serban
Junichi Shioi
Nikolaos K Robakis
Philippe Marambaud
Shula Sarner
Spiros Efthimiopoulos
Thomas Wisniewski
P2860
P304
P3181
P356
10.1093/EMBOJ/21.8.1948
P407
P577
2002-04-01T00:00:00Z