Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
about
The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophilsExtracellular BCL2 proteins are danger-associated molecular patterns that reduce tissue damage in murine models of ischemia-reperfusion injuryInnate immune pattern recognition: a cell biological perspectiveRole for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/AktMembrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif.Toll-like receptor-2 deficiency induces schizophrenia-like behaviors in micePhagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling.Insulin modulates the inflammatory granulocyte response to streptococci via phosphatidylinositol 3-kinase.TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase-dependent mechanism.Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis.Macrophage-activating lipopeptide-2 requires Mal and PI3K for efficient induction of heme oxygenase-1.TLR2 ligands induce cardioprotection against ischaemia/reperfusion injury through a PI3K/Akt-dependent mechanismTRAM is required for TLR2 endosomal signaling to type I IFN inductionTLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.Non-essential role for TLR2 and its signaling adaptor Mal/TIRAP in preserving normal lung architecture in miceTLR2 ligand induces protection against cerebral ischemia/reperfusion injury via activation of phosphoinositide 3-kinase/Akt signaling.Role of phosphoinositide 3-kinase-Akt signaling pathway in the age-related cytokine dysregulation in splenic macrophages stimulated via TLR-2 or TLR-4 receptorsUncoupling of pro- and anti-inflammatory properties of Staphylococcus aureus.Src-family-tyrosine kinase Lyn is critical for TLR2-mediated NF-κB activation through the PI 3-kinase signaling pathway.The role of phosphoinositide 3-kinase signaling in intestinal inflammationControl of adaptive immune responses by Staphylococcus aureus through IL-10, PD-L1, and TLR2Immunomodulation and Disease Tolerance to Staphylococcus aureusNegative regulation of TLR signaling in myeloid cells--implications for autoimmune diseases.Epithelial cells augment barrier function via activation of the Toll-like receptor 2/phosphatidylinositol 3-kinase pathway upon recognition of Salmonella enterica serovar Typhimurium curli fibrils in the gut.Streptococcus pneumoniae Endopeptidase O (PepO) Elicits a Strong Innate Immune Response in Mice via TLR2 and TLR4 Signaling Pathways.Adipose tissue insulin sensitivity and macrophage recruitment: Does PI3K pick the pathway?Toll-like receptors: new players in myocardial ischemia/reperfusion injury.Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3KMal, more than a bridge to MyD88.TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors.Evolving Bacterial Envelopes and Plasticity of TLR2-Dependent Responses: Basic Research and Translational OpportunitiesHeterodimer-specific TLR2 stimulation results in divergent functional outcomes in B-cell precursor acute lymphoblastic leukemia.Lipoteichoic acids as a major virulence factor causing inflammatory responses via Toll-like receptor 2.Phenotype and regulation of immunosuppressive Vδ2-expressing γδ T cellsCollagen VI regulates peripheral nerve regeneration by modulating macrophage recruitment and polarization.LPS induces the degradation of programmed cell death protein 4 (PDCD4) to release Twist2, activating c-Maf transcription to promote interleukin-10 productionDifferential adapter recruitment by TLR2 co-receptors.Small GTPase Rab8a-recruited Phosphatidylinositol 3-Kinase γ Regulates Signaling and Cytokine Outputs from Endosomal Toll-like Receptors.Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion.Porphyromonas gingivalis Stimulates TLR2-PI3K Signaling to Escape Immune Clearance and Induce Bone Resorption Independently of MyD88.
P2860
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P2860
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
@ast
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
@en
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
@en-gb
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
@nl
type
label
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
@ast
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
@en
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
@en-gb
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
@nl
prefLabel
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
@ast
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
@en
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
@en-gb
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
@nl
P2093
P2860
P356
P1433
P1476
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
@en
P2093
Douglas T Golenbock
Julia Kalnitski
Peter Küenzi
Philipp Henneke
Sachin D Deshmukh
Sandra Santos-Sierra
P2860
P304
P356
10.1038/EMBOJ.2009.158
P407
P577
2009-07-02T00:00:00Z