Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
about
Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1.A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcriptionIdentification and characterization of the human Set1B histone H3-Lys4 methyltransferase complexSolution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferaseCloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemiaProteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localizationCpG binding protein is crucial for early embryonic developmentThe elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesisMLL and CREB bind cooperatively to the nuclear coactivator CREB-binding proteinMCEF is localized to the nucleus by protein sequences encoded within three distinct exons, where it represses HIV-1 Tat-transactivation of LTR-directed transcriptionMLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell linesStructure and function of RNA polymerase II elongation factor ELL. Identification of two overlapping ELL functional domains that govern its interaction with polymerase and the ternary elongation complexModulation of cell cycle by graded expression of MLL-AF4 fusion oncoproteinInfertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemiaMouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemiaGenetic rearrangement MLL/AF4 is most frequent in children with acute lymphoblastic leukemias in Mexico City.CXXC finger protein 1 restricts the Setd1A histone H3K4 methyltransferase complex to euchromatin.c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis.Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots.Cytogenetics and molecular genetics of childhood leukemia.Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein.Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes.Leukemias related to treatment with DNA topoisomerase II inhibitors.Genetic evaluation of childhood acute lymphoblastic leukemia in Iraq using FTA cards.MLL fusion partners AF4 and AF9 interact at subnuclear foci.Novel domain combinations in proteins encoded by chimeric transcriptsFLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23).Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins.Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region.The structure of the human ALL-1/MLL/HRX gene.CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex.Mutant alleles of the Drosophila trithorax gene produce common and unusual homeotic and other developmental phenotypes.Molecular genetics of benign tumors.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiationLaf4/Aff3, a gene involved in intellectual disability, is required for cellular migration in the mouse cerebral cortex.MLL fusions: pathways to leukemia11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene.Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyondMLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).
P2860
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P2860
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
description
1993 nî lūn-bûn
@nan
1993 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
@ast
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
@en
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
@en-gb
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
@nl
type
label
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
@ast
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
@en
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
@en-gb
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
@nl
prefLabel
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
@ast
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
@en
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
@en-gb
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
@nl
P2093
P2860
P921
P356
P1476
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
@en
P2093
G A Silverman
J H Kersey
L Johansen
S J Korsmeyer
S S Fakharzadeh
P2860
P304
P356
10.1073/PNAS.90.16.7884
P407
P577
1993-08-15T00:00:00Z