MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein - Test2 - elhamkhani - TriplyDB

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

http://www.wikidata.org/entity/Q24550988

about

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis Leu628 of the KIX domain of CBP is a key residue for the interaction with the MLL transactivation domain Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases Cross-talk between histone modifications in response to histone deacetylase inhibitors: MLL4 links histone H3 acetylation and histone H3K4 methylation New insight into the molecular mechanisms of MLL-associated leukemia Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors Ca2+-dependent block of CREB-CBP transcription by repressor DREAM.Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP Critical role for a single leucine residue in leukemia induction by E2A-PBX1 MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein Genome-wide RNA polymerase II profiles and RNA accumulation reveal kinetics of transcription and associated epigenetic changes during diurnal cycles Intrinsic protein disorder in histone lysine methylation.Molecular Mechanism of MLL PHD3 and RNA Recognition by the Cyp33 RRM Domain Ordering a Dynamic Protein Via a Small-Molecule Stabilizer Allosteric Communication in the KIX Domain Proceeds through Dynamic Repacking of the Hydrophobic Core Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain Growth hormone-secreting tumors: genetic aspects and data from animal models CpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signals Regulation of MLL1 H3K4 methyltransferase activity by its core components Disordered epigenetic regulation in MLL-related leukemia.MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression.De novo mutations in MLL cause Wiedemann-Steiner syndrome.Identification of small-molecule antagonists that inhibit an activator: coactivator interaction.Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.Mixed lineage leukemia: a structure-function perspective of the MLL1 protein.MLL associates specifically with a subset of transcriptionally active target genes.Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes.p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation.Analysis of the coding genome of diffuse large B-cell lymphoma Inner workings and regulatory inputs that control Polycomb repressive complex 2 MLL fusion partners AF4 and AF9 interact at subnuclear foci.Shared structural features of the 9aaTAD family in complex with CBP.The molecular mechanics of mixed lineage leukemia.

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MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

http://www.wikidata.org/entity/Q24550988

description

2001 nî lūn-bûn

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2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2001年の論文

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2001年論文

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2001年論文

@zh-hant

2001年論文

@zh-hk

2001年論文

@zh-mo

2001年論文

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2001年论文

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name

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

@ast

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

@en

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

@nl

type

label

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

@ast

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

@en

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

@nl

prefLabel

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

@ast

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

@en

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

@nl

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MCB.21.7.2249-2258.2001

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Molecular and Cellular Biology

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MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

@en

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J Wang

http://www.w3.org/2001/XMLSchema#string

M Huang

http://www.w3.org/2001/XMLSchema#string

R H Goodman

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S J Korsmeyer

http://www.w3.org/2001/XMLSchema#string

P2860

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product

E1A directly binds and regulates the P/CAF acetyltransferase

Nuclear protein CBP is a coactivator for the transcription factor CREB

Association of SET domain and myotubularin-related proteins modulates growth control

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB

Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins

Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of CREB: A Model for Activator:Coactivator Interactions

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

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10.1128/MCB.21.7.2249-2258.2001

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