Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
about
Novel insights into the bovine polled phenotype and horn ontogenesis in BovidaeR-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5The spatial distribution of LGR5+ cells correlates with gastric cancer progressionTumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptorsA molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signallingZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive mannerConstitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi networkLGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressorInteraction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondinWnt/beta-catenin signaling and small molecule inhibitorsInternational Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligandsLGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signalingExtracellular Matrix Regulation of Stem Cell BehaviorMammary Development and Breast Cancer: A Wnt PerspectiveControl of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in CancerFrizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat CancerStem Cells in the Intestine: Possible Roles in Pathogenesis of Irritable Bowel SyndromeThe plastic cellular states of liver cells: Are EpCAM and Lgr5 fit for purpose?Organoid Models of Human Gastrointestinal Development and DiseaseEpithelial-mesenchymal transition in gastric cancerIn a Class of Their Own - RXFP1 and RXFP2 are Unique Members of the LGR FamilyMouse models of intestinal cancerReserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tractKeeping Wnt signalosome in check by vesicular trafficG Protein-Coupled Receptor Signaling in Stem Cells and CancerGenetic polymorphism in extracellular regulators of Wnt signaling pathwayAdult mammalian stem cells: the role of Wnt, Lgr5 and R-spondinsHow to make an intestineDefining hierarchies of stemness in the intestine: evidence from biomarkers and regulatory pathwaysThe R-spondin protein familyCellular signaling and biological functions of R-spondinsA rapid and affordable screening platform for membrane protein trafficking.The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids.LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea.Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions.The structural basis of R-spondin recognition by LGR5 and RNF43Structural basis for R-spondin recognition by LGR4/5/6 receptorsCrystal Structures of Lgr4 and Its Complex with R-Spondin1Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondinStructures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling
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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
@ast
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
@en
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
@en-gb
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
@nl
type
label
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
@ast
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
@en
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
@en-gb
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
@nl
prefLabel
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
@ast
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
@en
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
@en-gb
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
@nl
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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
@en
P2093
Albert J R Heck
Andrea Haegebarth
Hans Teunissen
Johan E van Es
Katsuhiko Nishimori
Marc van de Wetering
Nick Barker
Pekka Kujala
Peter J Peters
Richard B M Schasfoort
P2888
P3181
P356
10.1038/NATURE10337
P407
P50
P577
2011-08-18T00:00:00Z
P5875
P6179
1053455836