Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia - Test2 - elhamkhani - TriplyDB

Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia

Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia

http://www.wikidata.org/entity/Q24310753

about

Current concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia P-loop conformation governed crizotinib resistance in G2032R-mutated ROS1 tyrosine kinase: clues from free energy landscape Ectopic microRNA-150-5p transcription sensitizes glucocorticoid therapy response in MM1S multiple myeloma cells but fails to overcome hormone therapy resistance in MM1R cells IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study Pathway and network analysis of cancer genomes Inferring protein modulation from gene expression data using conditional mutual information.Glucocorticoid receptor β stimulates Akt1 growth pathway by attenuation of PTEN.Zebrafish as a model to assess cancer heterogeneity, progression and relapse.Identification of causal genetic drivers of human disease through systems-level analysis of regulatory networks.Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia PTEN: Multiple Functions in Human Malignant Tumors Assembly and interrogation of Alzheimer's disease genetic networks reveal novel regulators of progression A community computational challenge to predict the activity of pairs of compounds Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance.Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks Sustained interleukin-1β exposure modulates multiple steps in glucocorticoid receptor signaling, promoting split-resistance to the transactivation of prominent anti-inflammatory genes by glucocorticoids Identification of neurodegenerative factors using translatome-regulatory network analysis.Inhibition of the autocrine IL-6-JAK2-STAT3-calprotectin axis as targeted therapy for HR-/HER2+ breast cancers.MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia.Multivalent Small-Molecule Pan-RAS Inhibitors.Targeting Transcription Factors in Cancer HDAC6 activity is a non-oncogene addiction hub for inflammatory breast cancers Modulation of Glucocorticoid Resistance in Pediatric T-cell Acute Lymphoblastic Leukemia by Increasing BIM Expression with the PI3K/mTOR Inhibitor BEZ235 Impact of PTEN abnormalities on outcome in pediatric patients with T-cell acute lymphoblastic leukemia treated on the MRC UKALL2003 trial UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy.Functional characterization of somatic mutations in cancer using network-based inference of protein activity.Actions of Steroids: New Neurotransmitters.A systems approach to drug discovery in Alzheimer's disease.Functionally distinct patterns of nucleosome remodeling at enhancers in glucocorticoid-treated acute lymphoblastic leukemia.Outlook on PI3K/AKT/mTOR inhibition in acute leukemia.Glucocorticoids and Cancer.Oncogenic PTEN functions and models in T-cell malignancies.Personalization of dexamethasone therapy in childhood acute lymphoblastic leukaemia.Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia.JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias.Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment.

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Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia

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2013 nî lūn-bûn

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2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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Adolfo A Ferrando

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Ana Carolina Da Silva

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Arianne Perez-Garcia

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Isaura Rigo

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Jacob M Rowe

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Janis Racevskis

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Jiyang Yu

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Marta Sanchez-Martin

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P2860

Pten dose dictates cancer progression in the prostate

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Phosphorylation and regulation of Raf by Akt (protein kinase B)

Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death

Biology, risk stratification, and therapy of pediatric acute leukemias: an update.

Glucocorticoid use in acute lymphoblastic leukaemia

Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?

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