Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4 - Test2 - elhamkhani - TriplyDB

Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

http://www.wikidata.org/entity/Q24310773

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Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase Potential role for PAD2 in gene regulation in breast cancer cells.Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activity.Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives Born-Oppenheimer ab initio QM/MM molecular dynamics simulations of the hydrolysis reaction catalyzed by protein arginine deiminase 4.Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4.Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.Functional role of dimerization of human peptidylarginine deiminase 4 (PAD4).Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation.Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages.Citrullination of histone H3 interferes with HP1-mediated transcriptional repression.Kinetics of human peptidylarginine deiminase 2 (hPAD2)--reduction of Ca2+ dependence by phospholipids and assessment of proposed inhibition by paclitaxel side chains.Citrullination of inhibitor of growth 4 (ING4) by peptidylarginine deminase 4 (PAD4) disrupts the interaction between ING4 and p53 Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity.Extensive and varied modifications in histone H2B of wild-type and histone deacetylase 1 mutant Neurospora crassa Chemical biology of protein arginine modifications in epigenetic regulation Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice.Protein arginine deiminase 4: evidence for a reverse protonation mechanism.Activation of PAD4 in NET formation.Biology of the wool follicle: an excursion into a unique tissue interaction system waiting to be re-discovered.Protein Arginine Methylation and Citrullination in Epigenetic Regulation Structural dynamics of protein lysine methylation and demethylation.Protein arginine methyltransferases: from unicellular eukaryotes to humans Citrullination by peptidylarginine deiminase in rheumatoid arthritis.Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells.Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential Update on peptidylarginine deiminases and deimination in skin physiology and severe human diseases.Active site cysteine is protonated in the PAD4 Michaelis complex: evidence from Born-Oppenheimer ab initio QM/MM molecular dynamics simulations.Molecular Interplay between the Dimer Interface and the Substrate-Binding Site of Human Peptidylarginine Deiminase 4.The protein arginine deiminases: Structure, function, inhibition, and disease.Citrullination of autoantigens implicates NETosis in the induction of autoimmunity.Fingerprinting of anti-citrullinated protein antibodies (ACPA): specificity, isotypes and subclasses.Joint inflammation related citrullination of functional arginines in extracellular proteins.PAD4: pathophysiology, current therapeutics and future perspective in rheumatoid arthritis.PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation.Role of citrullination modification catalyzed by peptidylarginine deiminase 4 in gene transcriptional regulation.CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock.Peptidyl arginine deiminase inhibitor effect on hepatic fibrogenesis in a CCl4 pre-clinical model of liver fibrosis

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Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

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2006年論文

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Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

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Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

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Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

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Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

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Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

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Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

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Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

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Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

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Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

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Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

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Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

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Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

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Proceedings of the National Academy of Sciences of the United States of America

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Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

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Hiroshi Hashimoto

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Kyouhei Arita

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Mamoru Sato

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Michiyuki Yamada

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Toshiyuki Shimizu

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Yuji Hidaka

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P2860

Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3)

Crystal structure of the nucleosome core particle at 2.8 A resolution

Histone deimination antagonizes arginine methylation

Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis

Methylation at arginine 17 of histone H3 is linked to gene activation

Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination

Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies

Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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16567635

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histone citrullination

Peptidyl arginine deiminase 4

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1459348

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