Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3. - Test2 - elhamkhani - TriplyDB

Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.

Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.

http://www.wikidata.org/entity/Q33907872

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Citrullination of proteins: a common posttranslational modification pathway induced by different nanoparticles in vitro and in vivo Peptidylarginine Deiminases as Drug Targets in Neonatal Hypoxic-Ischemic Encephalopathy Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation Peptidylarginine deiminase and protein citrullination in prion diseases: strong evidence of neurodegeneration The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) i Synthesis and Screening of a Haloacetamidine Containing Library To Identify PAD4 Selective Inhibitors The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest Peptidylarginine Deiminase 3 (PAD3) Is Upregulated by Prolactin Stimulation of CID-9 Cells and Expressed in the Lactating Mouse Mammary Gland Protein-arginine deiminase 2 suppresses proliferation of colon cancer cells through protein citrullination Lupus and proliferative nephritis are PAD4 independent in murine models.Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4.Lowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown.Mechanistic similarity and diversity among the guanidine-modifying members of the pentein superfamily.A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs.Functional role of dimerization of human peptidylarginine deiminase 4 (PAD4).A fluopol-ABPP HTS assay to identify PAD inhibitors.Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity.Inhibiting protein arginine deiminases has antioxidant consequences.Activity-based protein profiling of protein arginine methyltransferase 1.Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method Chemical biology of protein arginine modifications in epigenetic regulation Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis.Potential role of peptidylarginine deiminase enzymes and protein citrullination in cancer pathogenesis.Activation of PAD4 in NET formation.Chemical Proteomic Platform To Identify Citrullinated Proteins Protein Arginine Methylation and Citrullination in Epigenetic Regulation Mechanistic studies of the agmatine deiminase from Listeria monocytogenes Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase-AIF pathway.The protein arginine deiminases: Structure, function, inhibition, and disease.Chemical and biological methods to detect post-translational modifications of arginine.L-arginine and nitric oxide in CNS function and neurodegenerative diseases.Epigenetic-based immune intervention for rheumatic diseases.Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy.Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy.

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P2860

Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.

http://www.wikidata.org/entity/Q33907872

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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Substrate specificity and kine ...... protein arginine deiminase 3.

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Substrate specificity and kine ...... protein arginine deiminase 3.

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Substrate specificity and kine ...... protein arginine deiminase 3.

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Substrate specificity and kine ...... protein arginine deiminase 3.

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Substrate specificity and kine ...... protein arginine deiminase 3.

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Substrate specificity and kine ...... protein arginine deiminase 3.

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Substrate specificity and kine ...... f protein arginine deiminase 3

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Christina J Dreyton

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Corey P Causey

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Hidenari Takahara

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Justin E Jones

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Monica Bhatia

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Paul R Thompson

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Tanesha C Osborne

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P2860

Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1

Histone deimination antagonizes arginine methylation

Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

Comparison of enzymatic properties between hPADI2 and hPADI4

cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I

Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination

Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies

The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis

Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse

Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

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4852-4863

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scholarly article

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10.1021/BI100363T

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23

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49

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20469888

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