Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain - Test2 - elhamkhani - TriplyDB

Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain

Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain

http://www.wikidata.org/entity/Q24311550

about

Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment The many roles of histone deacetylases in development and physiology: implications for disease and therapy Identification of a better Homo sapiens Class II HDAC inhibitor through binding energy calculations and descriptor analysis HDAC8 substrates: Histones and beyond Small molecule inhibitors of zinc-dependent histone deacetylases New and emerging HDAC inhibitors for cancer treatment HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration Loss of the putative catalytic domain of HDAC4 leads to reduced thermal nociception and seizures while allowing normal bone development Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors † , ‡Structures of Metal-Substituted Human Histone Deacetylase 8 Provide Mechanistic Inferences on Biological Function,Structure of Prokaryotic Polyamine Deacetylase Reveals Evolutionary Functional Relationships with Eukaryotic Histone Deacetylases,Crystal structure of human CRMP-4: correction of intensities for lattice-translocation disorder Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group Profiling technologies for the identification and characterization of small-molecule histone deacetylase inhibitors HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo Targeting Lysine Deacetylases (KDACs) in Parasites Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives Chemical phylogenetics of histone deacetylases.Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.Vorinostat-like molecules as structural, stereochemical, and pharmacological tools Activation and inhibition of histone deacetylase 8 by monovalent cations.Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions.Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.The clinical development of histone deacetylase inhibitors as targeted anticancer drugs.HDAC4: mechanism of regulation and biological functions Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents In silico modification of suberoylanilide hydroxamic acid (SAHA) as potential inhibitor for class II histone deacetylase (HDAC).Probing phosphorylation-dependent protein interactions within functional domains of histone deacetylase 5 (HDAC5).Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors.Eating disorder predisposition is associated with ESRRA and HDAC4 mutations Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein.Molecular modeling study on tunnel behavior in different histone deacetylase isoforms.Small-molecular modulators of cancer-associated epigenetic mechanisms.Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia.Histone deacetylase 4 alters cartilage homeostasis in human osteoarthritis.The histone deacetylase HDAC4 regulates long-term memory in Drosophila.Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes.Metabolism as a key to histone deacetylase inhibition.Mutagenesis Study Reveals the Rim of Catalytic Entry Site of HDAC4 and -5 as the Major Binding Surface of SMRT Corepressor Fragment based G-QSAR and molecular dynamics based mechanistic simulations into hydroxamic-based HDAC inhibitors against spinocerebellar ataxia.

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P2860

Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain

http://www.wikidata.org/entity/Q24311550

description

2008 nî lūn-bûn

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2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Structural and functional anal ...... structural zinc-binding domain

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Structural and functional anal ...... structural zinc-binding domain

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Structural and functional anal ...... structural zinc-binding domain

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Structural and functional anal ...... structural zinc-binding domain

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Structural and functional anal ...... structural zinc-binding domain

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Structural and functional anal ...... structural zinc-binding domain

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Structural and functional anal ...... structural zinc-binding domain

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Structural and functional anal ...... structural zinc-binding domain

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Structural and functional anal ...... structural zinc-binding domain

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Structural and functional anal ...... structural zinc-binding domain

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Structural and functional anal ...... structural zinc-binding domain

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Journal of Biological Chemistry

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Structural and functional anal ...... structural zinc-binding domain

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P2093

Agostino Cirillo

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Andrea Carfí

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Christian Steinkühler

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Federica Ferrigno

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Matthew J Bottomley

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Paola Gallinari

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Paola Lo Surdo

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Paolo Di Giovine

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Petra Neddermann

http://www.w3.org/2001/XMLSchema#string

Philip Jones

http://www.w3.org/2001/XMLSchema#string

P2860

Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR

Class II histone deacetylases: versatile regulators

Histone deacetylases (HDACs): characterization of the classical HDAC family

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

Crystal structure of a conserved N-terminal domain of histone deacetylase 4 reveals functional insights into glutamine-rich domains

Complex structure of a bacterial class 2 histone deacetylase homologue with a trifluoromethylketone inhibitor

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

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26694-704

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scholarly article

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10.1074/JBC.M803514200

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39

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283

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Raffaele De Francesco

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2008-09-26T00:00:00Z

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18614528

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peptidyl-lysine deacetylation

Histone deacetylase 4

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3258910

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