DENN, a novel human gene differentially expressed in normal and neoplastic cells
about
Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3Avl9p, a member of a novel protein superfamily, functions in the late secretory pathway.Induction of marked apoptosis in mammalian cancer cell lines by antisense DNA treatment to abolish expression of DENN (differentially expressed in normal and neoplastic cells)IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISCAkt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells.Knockdown of MADD and c-FLIP overcomes resistance to TRAIL-induced apoptosis in ovarian cancer cells.Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein.Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene.DENN domain proteins: regulators of Rab GTPases.MADD is a downstream target of PTEN in triggering apoptosis.C9orf72: At the intersection of lysosome cell biology and neurodegenerative disease.MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment.MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cells.
P2860
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P2860
DENN, a novel human gene differentially expressed in normal and neoplastic cells
description
1996 nî lūn-bûn
@nan
1996 թուականին հրատարակուած գիտական յօդուած
@hyw
1996 թվականին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
DENN, a novel human gene differentially expressed in normal and neoplastic cells
@ast
DENN, a novel human gene differentially expressed in normal and neoplastic cells
@en
DENN, a novel human gene differentially expressed in normal and neoplastic cells
@en-gb
DENN, a novel human gene differentially expressed in normal and neoplastic cells
@nl
type
label
DENN, a novel human gene differentially expressed in normal and neoplastic cells
@ast
DENN, a novel human gene differentially expressed in normal and neoplastic cells
@en
DENN, a novel human gene differentially expressed in normal and neoplastic cells
@en-gb
DENN, a novel human gene differentially expressed in normal and neoplastic cells
@nl
prefLabel
DENN, a novel human gene differentially expressed in normal and neoplastic cells
@ast
DENN, a novel human gene differentially expressed in normal and neoplastic cells
@en
DENN, a novel human gene differentially expressed in normal and neoplastic cells
@en-gb
DENN, a novel human gene differentially expressed in normal and neoplastic cells
@nl
P2860
P1433
P1476
DENN, a novel human gene differentially expressed in normal and neoplastic cells
@en
P2093
P2860
P304
P356
10.3109/10425179609020873
P407
P577
1996-01-01T00:00:00Z