Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene.
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Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4MADD knock-down enhances doxorubicin and TRAIL induced apoptosis in breast cancer cellsGenome-wide analysis of alternative splicing in medulloblastoma identifies splicing patterns characteristic of normal cerebellar development.Knockdown of MADD and c-FLIP overcomes resistance to TRAIL-induced apoptosis in ovarian cancer cells.miR-181 interacts with signaling adaptor molecule DENN/MADD and enhances TNF-induced cell deathDown-modulation of expression, or dephosphorylation, of IG20/MADD in tumor necrosis factor-related apoptosis-inducing ligand-resistant thyroid cancer cells makes them susceptible to treatment with this ligand.Knockdown of IG20 gene expression renders thyroid cancer cells susceptible to apoptosis.IG20/MADD plays a critical role in glucose-induced insulin secretion.DENN domain proteins: regulators of Rab GTPases.Alternative splicing as a biomarker and potential target for drug discovery.The mitochondrial apoptotic pathway is induced by Cu(II) antineoplastic compounds (Casiopeínas®) in SK-N-SH neuroblastoma cells after short exposure times.MADD is a downstream target of PTEN in triggering apoptosis.Potential cytotoxic and amoebicide activity of first row transition metal compounds with 2,9-bis-(2',5'-diazahexanyl)-1,1-phenanthroline (L1).MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment.Alternative Splicing as a Target for Cancer Treatment.
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P2860
Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on September 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Regulation of apoptosis and ca ...... by isoforms of the IG20 gene.
@en
Regulation of apoptosis and ca ...... by isoforms of the IG20 gene.
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type
label
Regulation of apoptosis and ca ...... by isoforms of the IG20 gene.
@en
Regulation of apoptosis and ca ...... by isoforms of the IG20 gene.
@nl
prefLabel
Regulation of apoptosis and ca ...... by isoforms of the IG20 gene.
@en
Regulation of apoptosis and ca ...... by isoforms of the IG20 gene.
@nl
P2093
P2860
P1433
P1476
Regulation of apoptosis and ca ...... by isoforms of the IG20 gene.
@en
P2093
Bellur S Prabhakar
Jian Rong Sheng
Liang Cheng Li
Matthew N Meriggioli
Nirupama Mulherkar
P2860
P304
P356
10.1158/0008-5472.CAN-07-6311
P407
P577
2008-09-01T00:00:00Z