Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene. - Test2 - elhamkhani - TriplyDB

Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene.

Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene.

http://www.wikidata.org/entity/Q37383857

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Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4 MADD knock-down enhances doxorubicin and TRAIL induced apoptosis in breast cancer cells Genome-wide analysis of alternative splicing in medulloblastoma identifies splicing patterns characteristic of normal cerebellar development.Knockdown of MADD and c-FLIP overcomes resistance to TRAIL-induced apoptosis in ovarian cancer cells.miR-181 interacts with signaling adaptor molecule DENN/MADD and enhances TNF-induced cell death Down-modulation of expression, or dephosphorylation, of IG20/MADD in tumor necrosis factor-related apoptosis-inducing ligand-resistant thyroid cancer cells makes them susceptible to treatment with this ligand.Knockdown of IG20 gene expression renders thyroid cancer cells susceptible to apoptosis.IG20/MADD plays a critical role in glucose-induced insulin secretion.DENN domain proteins: regulators of Rab GTPases.Alternative splicing as a biomarker and potential target for drug discovery.The mitochondrial apoptotic pathway is induced by Cu(II) antineoplastic compounds (Casiopeínas®) in SK-N-SH neuroblastoma cells after short exposure times.MADD is a downstream target of PTEN in triggering apoptosis.Potential cytotoxic and amoebicide activity of first row transition metal compounds with 2,9-bis-(2',5'-diazahexanyl)-1,1-phenanthroline (L1).MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment.Alternative Splicing as a Target for Cancer Treatment.

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Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene.

http://www.wikidata.org/entity/Q37383857

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on September 2008

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Regulation of apoptosis and ca ...... by isoforms of the IG20 gene.

@en

Regulation of apoptosis and ca ...... by isoforms of the IG20 gene.

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type

label

Regulation of apoptosis and ca ...... by isoforms of the IG20 gene.

@en

Regulation of apoptosis and ca ...... by isoforms of the IG20 gene.

@nl

prefLabel

Regulation of apoptosis and ca ...... by isoforms of the IG20 gene.

@en

Regulation of apoptosis and ca ...... by isoforms of the IG20 gene.

@nl

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0008-5472.CAN-07-6311

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Cancer Research

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Regulation of apoptosis and ca ...... by isoforms of the IG20 gene.

@en

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Bellur S Prabhakar

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Jian Rong Sheng

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Liang Cheng Li

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Matthew N Meriggioli

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Nirupama Mulherkar

http://www.w3.org/2001/XMLSchema#string

P2860

Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3

DENN, a novel human gene differentially expressed in normal and neoplastic cells

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase

Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons

A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system

A system for stable expression of short interfering RNAs in mammalian cells

IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth

IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro

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23259842

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18794122

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apoptotic process

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