The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1
about
The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia proteinDNA methylation pathways and their crosstalk with histone methylationAn insight into the various regulatory mechanisms modulating human DNA methyltransferase 1 stability and functionStructural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) ProteinSignalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancerDNA methylation, its mediators and genome integrityMBD4 interacts with and recruits USP7 to heterochromatic fociCrystal Structure of USP7 Ubiquitin-like Domains with an ICP0 Peptide Reveals a Novel Mechanism Used by Viral and Cellular Proteins to Target USP7USP7 is a SUMO deubiquitinase essential for DNA replicationPoly(ADP-ribose) polymerase 1 (PARP1) associates with E3 ubiquitin-protein ligase UHRF1 and modulates UHRF1 biological functionsUsp7 protects genomic stability by regulating Bub3.The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes.The emerging nexus of active DNA demethylation and mitochondrial oxidative metabolism in post-mitotic neuronsMolecular mechanism for USP7-mediated DNMT1 stabilization by acetylation.Characterization of Dnmt1 Binding and DNA Methylation on Nucleosomes and Nucleosomal ArraysM phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability.Crystal Structure of Human DNA Methyltransferase 1HAUSP-nucleolin interaction is regulated by p53-Mdm2 complex in response to DNA damage responseAn Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1.RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylationPediatric cancer epigenome and the influence of folateLong noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1.UHRF1 regulation of Dnmt1 is required for pre-gastrula zebrafish development.HBP1-mediated transcriptional regulation of DNA methyltransferase 1 and its impact on cell senescence.Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity.A novel hypoxia-selective epigenetic agent RRx-001 triggers apoptosis and overcomes drug resistance in multiple myeloma cells.The WD40-repeat protein-containing deubiquitinase complex: catalysis, regulation, and potential for therapeutic intervention.CDDO-Me reveals USP7 as a novel target in ovarian cancer cells.CG hypomethylation in Lsh-/- mouse embryonic fibroblasts is associated with de novo H3K4me1 formation and altered cellular plasticity.Ub-family modifications at the replication fork: Regulating PCNA-interacting components.Regulation of protein stability of DNA methyltransferase 1 by post-translational modificationsEpigenetics in T-cell acute lymphoblastic leukemia.Regulation of maintenance DNA methylation via histone ubiquitylation.Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.Structural Characterization of Interaction between Human Ubiquitin-specific Protease 7 and Immediate-Early Protein ICP0 of Herpes Simplex Virus-1.DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitinationUSP7 is essential for maintaining Rad18 stability and DNA damage tolerance.A Protein Interaction between β-Catenin and Dnmt1 Regulates Wnt Signaling and DNA Methylation in Colorectal Cancer Cells.Allosteric control of mammalian DNA methyltransferases - a new regulatory paradigm.Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication.
P2860
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P248
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P2860
The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The USP7/Dnmt1 complex stimula ...... gulates the stability of UHRF1
@ast
The USP7/Dnmt1 complex stimula ...... gulates the stability of UHRF1
@en
The USP7/Dnmt1 complex stimula ...... gulates the stability of UHRF1
@en-gb
The USP7/Dnmt1 complex stimula ...... gulates the stability of UHRF1
@nl
type
label
The USP7/Dnmt1 complex stimula ...... gulates the stability of UHRF1
@ast
The USP7/Dnmt1 complex stimula ...... gulates the stability of UHRF1
@en
The USP7/Dnmt1 complex stimula ...... gulates the stability of UHRF1
@en-gb
The USP7/Dnmt1 complex stimula ...... gulates the stability of UHRF1
@nl
prefLabel
The USP7/Dnmt1 complex stimula ...... gulates the stability of UHRF1
@ast
The USP7/Dnmt1 complex stimula ...... gulates the stability of UHRF1
@en
The USP7/Dnmt1 complex stimula ...... gulates the stability of UHRF1
@en-gb
The USP7/Dnmt1 complex stimula ...... gulates the stability of UHRF1
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
The USP7/Dnmt1 complex stimula ...... gulates the stability of UHRF1
@en
P2093
Attila Németh
Saskia Joppien
Thomas Dobner
Verena Thalhammer
P2860
P304
P3181
P356
10.1093/NAR/GKR528
P407
P577
2011-10-01T00:00:00Z