Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis
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Control of adult neurogenesis by programmed cell death in the mammalian brainPhotoreceptor cell death and rescue in retinal detachment and degenerationsThe BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer TherapeuticsIntegration and oligomerization of Bax protein in lipid bilayers characterized by single molecule fluorescence studyBID-induced structural changes in BAK promote apoptosisStructural Insights of tBid, the Caspase-8-activated Bid, and Its BH3 DomainStructural Insight into BH3 Domain Binding of Vaccinia Virus Antiapoptotic F1LBh3 induced conformational changes in Bcl-Xl revealed by crystal structure and comparative analysisStructural basis of Deerpox virus-mediated inhibition of apoptosisMitochondrial apoptosis and BH3 mimeticsPutting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosisCasp8p41 generated by HIV protease kills CD4 T cells through direct Bak activationTCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xLBuilding blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosisAssembly of Bak homodimers into higher order homooligomers in the mitochondrial apoptotic poreDirect Activation of Bax Protein for Cancer TherapyThe functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains.GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell deathSynthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site.Pushing the size limit of de novo structure ensemble prediction guided by sparse SDSL-EPR restraints to 200 residues: The monomeric and homodimeric forms of BAXPro-apoptotic Bax molecules densely populate the edges of membrane pores.Nutation frequency modulation on NMR signal of nuclear spins in chemical exchange with solvent water under the BEST conditions.Measuring translational diffusion coefficients of peptides and proteins by PFG-NMR using band-selective RF pulses.Assembling the puzzle: Oligomerization of α-pore forming proteins in membranesRelease of Cytochrome C from Bax Pores at the Mitochondrial Membrane.Histone deacetylase inhibitors interrupt HSP90•RASGRP1 and HSP90•CRAF interactions to upregulate BIM and circumvent drug resistance in lymphoma cellsThe rheostat in the membrane: BCL-2 family proteins and apoptosisPlatelet-derived growth factor primes cancer-associated fibroblasts for apoptosis.Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy responseApoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membraneA plug release mechanism for membrane permeation by MLKL.Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis.Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate.Visual and functional demonstration of growing Bax-induced pores in mitochondrial outer membranes.Polydatin attenuates ipopolysaccharide-induced acute lung injury in rats.Roscovitine-induced apoptosis in neutrophils and neutrophil progenitors is regulated by the Bcl-2-family members Bim, Puma, Noxa and Mcl-1Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim.The pro-apoptotic BH3-only protein Bim interacts with components of the translocase of the outer mitochondrial membrane (TOM)
P2860
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P2860
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis
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2013 nî lūn-bûn
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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2013年の論文
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2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Bax crystal structures reveal ...... merization to induce apoptosis
@ast
Bax crystal structures reveal ...... merization to induce apoptosis
@en
Bax crystal structures reveal ...... merization to induce apoptosis
@en-gb
Bax crystal structures reveal ...... merization to induce apoptosis
@nl
type
label
Bax crystal structures reveal ...... merization to induce apoptosis
@ast
Bax crystal structures reveal ...... merization to induce apoptosis
@en
Bax crystal structures reveal ...... merization to induce apoptosis
@en-gb
Bax crystal structures reveal ...... merization to induce apoptosis
@nl
prefLabel
Bax crystal structures reveal ...... merization to induce apoptosis
@ast
Bax crystal structures reveal ...... merization to induce apoptosis
@en
Bax crystal structures reveal ...... merization to induce apoptosis
@en-gb
Bax crystal structures reveal ...... merization to induce apoptosis
@nl
P2093
P50
P921
P3181
P1433
P1476
Bax crystal structures reveal ...... merization to induce apoptosis
@en
P2093
Adeline Y Robin
Dana Westphal
David C S Huang
Grant Dewson
Jerry M Adams
Peter E Czabotar
Peter M Colman
Stephen Ma
W Douglas Fairlie
P304
P3181
P356
10.1016/J.CELL.2012.12.031
P407
P577
2013-01-31T00:00:00Z