The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development
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Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamicsCilia/Ift protein and motor -related bone diseases and mouse modelsCooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapyHedgehog signaling pathway in ovarian cancerKinesin motors and primary ciliaInositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathiesDecoding the phosphorylation code in Hedgehog signal transductionStructural insights into human Kif7, a kinesin involved in Hedgehog signallingThe Hedgehog signalling pathway in bone formationThe many faces of KIF7Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesisFuz mutant mice reveal shared mechanisms between ciliopathies and FGF-related syndromesThe IFT-A complex regulates Shh signaling through cilia structure and membrane protein traffickingBroad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transductionA Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia ElongationMouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signalingThe primary cilium: a signalling centre during vertebrate developmentBifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.Planarian Hh signaling regulates regeneration polarity and links Hh pathway evolution to ciliaCoordinated translocation of mammalian Gli proteins and suppressor of fused to the primary ciliumGli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish.The kinesin motor protein Kif7 is required for T-cell development and normal MHC expression on thymic epithelial cells (TEC) in the thymus.The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartmentMechanism and evolution of cytosolic Hedgehog signal transductionCilia in the CNS: the quiet organelle claims center stageKIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes.Downregulation of the gli transcription factors regulator Kif7 facilitates cell survival and migration of choriocarcinoma cells.CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction.Primary cilia in pancreatic development and disease.Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling.Smoothened Regulation: A Tale of Two Signals.Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo.Clinical implications of hedgehog signaling pathway inhibitorsThe heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog ResponseHedgehog secretion and signal transduction in vertebrates.Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination.Ciliary Entry of the Hedgehog Transcriptional Activator Gli2 Is Mediated by the Nuclear Import Machinery but Differs from Nuclear Transport in Being Imp-α/β1-IndependentHedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation.
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P2860
The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The mammalian Cos2 homolog Kif ...... ransduction during development
@ast
The mammalian Cos2 homolog Kif ...... ransduction during development
@en
The mammalian Cos2 homolog Kif ...... ransduction during development
@en-gb
The mammalian Cos2 homolog Kif ...... ransduction during development
@nl
type
label
The mammalian Cos2 homolog Kif ...... ransduction during development
@ast
The mammalian Cos2 homolog Kif ...... ransduction during development
@en
The mammalian Cos2 homolog Kif ...... ransduction during development
@en-gb
The mammalian Cos2 homolog Kif ...... ransduction during development
@nl
prefLabel
The mammalian Cos2 homolog Kif ...... ransduction during development
@ast
The mammalian Cos2 homolog Kif ...... ransduction during development
@en
The mammalian Cos2 homolog Kif ...... ransduction during development
@en-gb
The mammalian Cos2 homolog Kif ...... ransduction during development
@nl
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P921
P3181
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The mammalian Cos2 homolog Kif ...... ransduction during development
@en
P2093
Andrew S Peterson
Deanna Wilson
Frederic J de Sauvage
Jan-Willem Theunissen
Khanhky Phamluong
Marie Evangelista
Mark J Solloway
Matti Davis
Setsu Endoh-Yamagami
Xiaohui Wen
P304
P3181
P356
10.1016/J.CUB.2009.06.046
P407
P577
2009-07-09T00:00:00Z