A novel switch region regulates H-ras membrane orientation and signal output
about
Disruption of RAB40AL function leads to Martin--Probst syndrome, a rare X-linked multisystem neurodevelopmental human disorderThe Ras protein superfamily: evolutionary tree and role of conserved amino acidsPhosphorylation-induced conformational changes in Rap1b: allosteric effects on switch domains and effector loopPrinciples and Overview of Sampling Methods for Modeling Macromolecular Structure and DynamicsNovel allosteric sites on Ras for lead generationThe distinct conformational dynamics of K-Ras and H-Ras A59GRas conformational switching: simulating nucleotide-dependent conformational transitions with accelerated molecular dynamicsA restricted spectrum of NRAS mutations causes Noonan syndromeAnalysis of Binding Site Hot Spots on the Surface of Ras GTPaseCellular FRET-Biosensors to Detect Membrane Targeting Inhibitors of N-Myristoylated ProteinspMD-Membrane: A Method for Ligand Binding Site Identification in Membrane-Bound ProteinsHigh-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autismH-Ras forms dimers on membrane surfaces via a protein-protein interface.Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pair motionsRas, an actor on many stages: posttranslational modifications, localization, and site-specified events.H-Ras nanocluster stability regulates the magnitude of MAPK signal outputRas membrane orientation and nanodomain localization generate isoform diversityLarge conformational changes in proteins: signaling and other functions.Nucleotide binding switches the information flow in ras GTPases.Nucleophosmin and nucleolin regulate K-Ras signaling.An N-terminal polybasic motif of Gαq is required for signaling and influences membrane nanodomain distribution.Cells respond to mechanical stress by rapid disassembly of caveolae.Oligomerization and nanocluster organization render specificity.Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region.Binding hotspots on K-ras: consensus ligand binding sites and other reactive regions from probe-based molecular dynamics analysis.Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.Revealing conformational substates of lipidated N-Ras protein by pressure modulation.Automated High-Throughput Fluorescence Lifetime Imaging Microscopy to Detect Protein-Protein Interactions.Nonsteroidal anti-inflammatory drugs alter the spatiotemporal organization of Ras proteins on the plasma membrane.Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation.Ras trafficking, localization and compartmentalized signallingASPP2 Is a Novel Pan-Ras Nanocluster Scaffold.Multiscale Simulations Suggest a Mechanism for the Association of the Dok7 PH Domain with PIP-Containing Membranes.SPRED1 Interferes with K-ras but Not H-ras Membrane Anchorage and Signaling.Overview of simulation studies on the enzymatic activity and conformational dynamics of the GTPase Ras.The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding RegionsFormation and domain partitioning of H-ras peptide nanoclusters: effects of peptide concentration and lipid composition.The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretaseSpecific Conformational States of Ras GTPase upon Effector BindingThe disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding.
P2860
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P2860
A novel switch region regulates H-ras membrane orientation and signal output
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
A novel switch region regulates H-ras membrane orientation and signal output
@ast
A novel switch region regulates H-ras membrane orientation and signal output
@en
A novel switch region regulates H-ras membrane orientation and signal output
@en-gb
A novel switch region regulates H-ras membrane orientation and signal output
@nl
type
label
A novel switch region regulates H-ras membrane orientation and signal output
@ast
A novel switch region regulates H-ras membrane orientation and signal output
@en
A novel switch region regulates H-ras membrane orientation and signal output
@en-gb
A novel switch region regulates H-ras membrane orientation and signal output
@nl
prefLabel
A novel switch region regulates H-ras membrane orientation and signal output
@ast
A novel switch region regulates H-ras membrane orientation and signal output
@en
A novel switch region regulates H-ras membrane orientation and signal output
@en-gb
A novel switch region regulates H-ras membrane orientation and signal output
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
A novel switch region regulates H-ras membrane orientation and signal output
@en
P2093
Alemayehu A Gorfe
John F Hancock
Michael Hanzal-Bayer
Nicolas Ariotti
Sarah J Plowman
P2860
P304
P3181
P356
10.1038/EMBOJ.2008.10
P407
P577
2008-03-05T00:00:00Z