High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism
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iPSC-derived neurons as a higher-throughput readout for autism: promises and pitfallsTwo knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis.Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.Overexpression of Homer1a in the basal and lateral amygdala impairs fear conditioning and induces an autism-like social impairmentGenetic aspects of autism spectrum disorders: insights from animal modelsA Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Impairment of translation in neurons as a putative causative factor for autismAn evo-devo approach to thyroid hormones in cerebral and cerebellar cortical development: etiological implications for autismSynaptic proteins and receptors defects in autism spectrum disordersSelective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice.Stem cells and modeling of autism spectrum disorders.Gestational and early postnatal hypothyroidism alters VGluT1 and VGAT bouton distribution in the neocortex and hippocampus, and behavior in rats.mGluR5 ablation in cortical glutamatergic neurons increases novelty-induced locomotionExcitatory/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis.Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and AutismAutistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity.GRIP1 is required for homeostatic regulation of AMPAR traffickingElevated CaMKIIα and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model.Lighting a path: genetic studies pinpoint neurodevelopmental mechanisms in autism and related disorders.Lack of association of rare functional variants in TSC1/TSC2 genes with autism spectrum disorderImpairment of fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling and its downstream cognates ras-related C3 botulinum toxin substrate 1, amyloid beta A4 precursor protein, striatal-enriched protein tyrosine phosphatase,Receptor Tyrosine Kinase MET Interactome and Neurodevelopmental Disorder Partners at the Developing Synapse.Shank mutant mice as an animal model of autism.The role of ionotropic glutamate receptors in childhood neurodevelopmental disorders: autism spectrum disorders and fragile x syndrome.Proteomic Analysis of Post-synaptic Density Fractions from Shank3 Mutant Mice Reveals Brain Region Specific Changes Relevant to Autism Spectrum Disorder.Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders.Activity-dependent neuronal signalling and autism spectrum disorder.Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: relevance to schizophrenia and other behavioral disorders pathophysiology, and implications for novel therapeutic approaches.High-throughput sequencing of autism spectrum disorders comes of age.A blueprint for research on Shankopathies: a view from research on autism spectrum disorder.Glutamatergic candidate genes in autism spectrum disorder: an overview.Advancing the discovery of medications for autism spectrum disorder using new technologies to reveal social brain circuitry in rodents.Synaptic basis of social dysfunction: a focus on postsynaptic proteins linking group-I mGluRs with AMPARs and NMDARs.Hepatitis C virus genetic variability and evolution.Perturbed proteostasis in autism spectrum disorders.Common variants in genes of the postsynaptic FMRP signalling pathway are risk factors for autism spectrum disorders.Rheb1 mediates DISC1-dependent regulation of new neuron development in the adult hippocampus.Disturbed cingulate glutamate metabolism in adults with high-functioning autism spectrum disorder: evidence in support of the excitatory/inhibitory imbalance hypothesis.Behavioral and Neurochemical Phenotyping of Mice Incapable of Homer1a Induction.Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning.
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High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism
description
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique PLoS ONE
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artículu científicu espublizáu en 2012
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im Januar 2012 veröffentlichter wissenschaftlicher Artikel
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scientific article (publication date: 2012)
@en
vedecký článok (publikovaný 2012)
@sk
vědecký článek publikovaný v roce 2012
@cs
wetenschappelijk artikel (gepubliceerd in 2012)
@nl
наукова стаття, опублікована у 2012
@uk
name
High-throughput sequencing of ...... ent of rare variants in autism
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High-throughput sequencing of ...... ent of rare variants in autism
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High-throughput sequencing of ...... ent of rare variants in autism
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type
label
High-throughput sequencing of ...... ent of rare variants in autism
@ast
High-throughput sequencing of ...... ent of rare variants in autism
@en
High-throughput sequencing of ...... ent of rare variants in autism
@nl
prefLabel
High-throughput sequencing of ...... ent of rare variants in autism
@ast
High-throughput sequencing of ...... ent of rare variants in autism
@en
High-throughput sequencing of ...... ent of rare variants in autism
@nl
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High-throughput sequencing of ...... ent of rare variants in autism
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Barbara Rathmell
David Margulies
Edwin Trautman
Hayk Hovhannisyan
Randall Carpenter
Raymond J Kelleher
Robert Pinard
Ute Geigenmüller
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P304
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10.1371/JOURNAL.PONE.0035003
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P577
2012-01-01T00:00:00Z