Plk1-mediated phosphorylation of Topors regulates p53 stability
about
Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnoverPLK-1 Targeted Inhibitors and Their Potential against TumorigenesisPolo-like kinase 1, on the rise from cell cycle regulation to prostate cancer developmentRho kinase proteins--pleiotropic modulators of cell survival and apoptosisThe SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition.Functional Significance of Aurora Kinases-p53 Protein Family Interactions in CancerCross Talk between Wnt/β-Catenin and CIP2A/Plk1 Signaling in Prostate Cancer: Promising Therapeutic ImplicationsPolo-like kinase and its inhibitors: Ready for the match to start?Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, ToporsCombinatorial inhibition of Plk1 and PKCβ in cancer cells with different p53 statusMutant TP53 posttranslational modifications: challenges and opportunities.Polo-box domain: a versatile mediator of polo-like kinase function.Inhibition of polo-like kinase 1 (Plk1) enhances the antineoplastic activity of metformin in prostate cancer.Polo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidySUMOylation of mouse p53b by SUMO-1 promotes its pro-apoptotic function in ovarian granulosa cells.The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.PLK1 and HOTAIR Accelerate Proteasomal Degradation of SUZ12 and ZNF198 during Hepatitis B Virus-Induced Liver CarcinogenesisTargeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer TreatmentTOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene.Polo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication.DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destructionSumoylation and regulation of cardiac gene expression.Plk1 phosphorylation of Topors is involved in its degradation.Impact of Polo-like kinase 1 inhibitors on human adipose tissue-derived mesenchymal stem cells.The substrates of Plk1, beyond the functions in mitosis.Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy.SUMO rules: regulatory concepts and their implication in neurologic functions.The role of polo-like kinase 1 in carcinogenesis: cause or consequence?Polo-like kinase-1 in DNA damage response.Current assessment of polo-like kinases as anti-tumor drug targets.Indirect p53-dependent transcriptional repression of Survivin, CDC25C, and PLK1 genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complex.Small molecule inhibition of polo-like kinase 1 by volasertib (BI 6727) causes significant melanoma growth delay and regression in vivo.Inhibition of Polo-like kinase 1 during the DNA damage response is mediated through loss of Aurora A recruitment by Bora.Molecular interactions of polo-like kinase 1 in human cancers.Combining p53 stabilizers with metformin induces synergistic apoptosis through regulation of energy metabolism in castration-resistant prostate cancer.Low-dose arsenic-mediated metabolic shift is associated with activation of Polo-like kinase 1 (Plk1).Plk1 Inhibitors in Cancer Therapy: From Laboratory to Clinics.Plk1 inhibition enhances the efficacy of androgen signaling blockade in castration-resistant prostate cancer.Large-scale label-free comparative proteomics analysis of polo-like kinase 1 inhibition via the small-molecule inhibitor BI 6727 (Volasertib) in BRAF(V600E) mutant melanoma cells.Targeting polo-like kinase 1 suppresses essential functions of alloreactive T cells.
P2860
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P2860
Plk1-mediated phosphorylation of Topors regulates p53 stability
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Plk1-mediated phosphorylation of Topors regulates p53 stability
@ast
Plk1-mediated phosphorylation of Topors regulates p53 stability
@en
Plk1-mediated phosphorylation of Topors regulates p53 stability
@en-gb
Plk1-mediated phosphorylation of Topors regulates p53 stability
@nl
type
label
Plk1-mediated phosphorylation of Topors regulates p53 stability
@ast
Plk1-mediated phosphorylation of Topors regulates p53 stability
@en
Plk1-mediated phosphorylation of Topors regulates p53 stability
@en-gb
Plk1-mediated phosphorylation of Topors regulates p53 stability
@nl
prefLabel
Plk1-mediated phosphorylation of Topors regulates p53 stability
@ast
Plk1-mediated phosphorylation of Topors regulates p53 stability
@en
Plk1-mediated phosphorylation of Topors regulates p53 stability
@en-gb
Plk1-mediated phosphorylation of Topors regulates p53 stability
@nl
P2093
P2860
P921
P356
P1476
Plk1-mediated phosphorylation of Topors regulates p53 stability
@en
P2093
Anping Deng
Hongchang Li
Wen-Horng Wang
Xiaoming Yang
Xiaoqi Liu
Zinan Zhou
P2860
P304
P356
10.1074/JBC.C109.001560
P407
P577
2009-07-10T00:00:00Z