The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies
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topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damageTopors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor proteinPlk1-mediated phosphorylation of Topors regulates p53 stabilityTOPORS, implicated in retinal degeneration, is a cilia-centrosomal proteinInflammatory cytokines induce phosphorylation and ubiquitination of prostate suppressor protein NKX3.1The accessible chromatin landscape of the human genomeMutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophyThe topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressorTopors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivoResidues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitroDeficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice.Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, ToporsA manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics.SUMO conjugation attenuates the activity of the gypsy chromatin insulator.Transcription-dependent degradation of topoisomerase I-DNA covalent complexesNuclear structure and chromosome segregation in Drosophila male meiosis depend on the ubiquitin ligase dTopors.Plk1 phosphorylation of Topors is involved in its degradation.The substrates of Plk1, beyond the functions in mitosis.The E3 ligase Topors induces the accumulation of polysumoylated forms of DNA topoisomerase I in vitro and in vivo.
P2860
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P2860
The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The topoisomerase I-binding RI ...... ocytic leukemia nuclear bodies
@ast
The topoisomerase I-binding RI ...... ocytic leukemia nuclear bodies
@en
The topoisomerase I-binding RI ...... ocytic leukemia nuclear bodies
@nl
type
label
The topoisomerase I-binding RI ...... ocytic leukemia nuclear bodies
@ast
The topoisomerase I-binding RI ...... ocytic leukemia nuclear bodies
@en
The topoisomerase I-binding RI ...... ocytic leukemia nuclear bodies
@nl
prefLabel
The topoisomerase I-binding RI ...... ocytic leukemia nuclear bodies
@ast
The topoisomerase I-binding RI ...... ocytic leukemia nuclear bodies
@en
The topoisomerase I-binding RI ...... ocytic leukemia nuclear bodies
@nl
P2093
P356
P1476
The topoisomerase I-binding RI ...... ocytic leukemia nuclear bodies
@en
P2093
Ahamed Saleem
Eric H Rubin
Yaniv Ravee
Zeshaan A Rasheed
P304
P356
10.1006/EXCR.2002.5550
P407
P577
2002-07-15T00:00:00Z