Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt
about
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptorsPhosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase ItchZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive mannerControl of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in CancerThe business of deubiquitination - location, location, locationKeeping Wnt signalosome in check by vesicular trafficDecoding the phosphorylation code in Hedgehog signal transductionThe Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in DrosophilaA Wnt-planar polarity pathway instructs neurite branching by restricting F-actin assembly through endosomal signaling.Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function.USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localizationHedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila.Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes.Updating the Wnt pathways.Systematic analysis of the physiological importance of deubiquitinating enzymes.Insulin-regulated trafficking of GLUT4 requires ubiquitinationMolecular Role of RNF43 in Canonical and Noncanonical Wnt SignalingUbiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerizationDeubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling.Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8.Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes.USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signalsA functional endosomal pathway is necessary for lysosome biogenesis in Drosophila.Ubiquitination of G protein-coupled receptors: functional implications and drug discovery.CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in DrosophilaA targeted in vivo RNAi screen reveals deubiquitinases as new regulators of Notch signaling.Sorting nexin 27 interacts with Fzd7 and mediates Wnt signalling.Ubiquitin-specific protease 4 controls metastatic potential through β-catenin stabilization in brain metastatic lung adenocarcinomaHectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.Minireview: ubiquitination-regulated G protein-coupled receptor signaling and traffickingA Cul-3-BTB ubiquitylation pathway regulates junctional levels and asymmetry of core planar polarity proteinsThe spatial and temporal organization of ubiquitin networksUSP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds.Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.Protein kinase PKN1 represses Wnt/β-catenin signaling in human melanoma cells.The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans.Ubpy controls the stability of the ESCRT-0 subunit Hrs in development.The various roles of ubiquitin in Wnt pathway regulation.How ubiquitin functions with ESCRTsShaping development with ESCRTs.
P2860
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P2860
Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Balanced ubiquitylation and de ...... lular responsiveness to Wg/Wnt
@ast
Balanced ubiquitylation and de ...... lular responsiveness to Wg/Wnt
@en
Balanced ubiquitylation and de ...... lular responsiveness to Wg/Wnt
@en-gb
Balanced ubiquitylation and de ...... lular responsiveness to Wg/Wnt
@nl
type
label
Balanced ubiquitylation and de ...... lular responsiveness to Wg/Wnt
@ast
Balanced ubiquitylation and de ...... lular responsiveness to Wg/Wnt
@en
Balanced ubiquitylation and de ...... lular responsiveness to Wg/Wnt
@en-gb
Balanced ubiquitylation and de ...... lular responsiveness to Wg/Wnt
@nl
prefLabel
Balanced ubiquitylation and de ...... lular responsiveness to Wg/Wnt
@ast
Balanced ubiquitylation and de ...... lular responsiveness to Wg/Wnt
@en
Balanced ubiquitylation and de ...... lular responsiveness to Wg/Wnt
@en-gb
Balanced ubiquitylation and de ...... lular responsiveness to Wg/Wnt
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Balanced ubiquitylation and de ...... lular responsiveness to Wg/Wnt
@en
P2093
Akiko Mukai
Masayuki Komada
Miki Yamamoto-Hino
Satoshi Goto
Wakae Awano
Wakako Watanabe
P2860
P304
P3181
P356
10.1038/EMBOJ.2010.100
P407
P577
2010-07-07T00:00:00Z