Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: a link to the sex determination cascade
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The herbicide atrazine activates endocrine gene networks via non-steroidal NR5A nuclear receptors in fish and mammalian cellsThe role of human MBF1 as a transcriptional coactivatorInsensitivity to anti-müllerian hormone due to a mutation in the human anti-müllerian hormone receptorDirect interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Müllerian hormone genePtx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domainEgr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcriptionMice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroidsBioactivation of Müllerian inhibiting substance during gonadal development by a kex2/subtilisin-like endoproteaseContemporary genetic technologies and female reproductionMutations in NR5A1 associated with ovarian insufficiencySF-1 a key player in the development and differentiation of steroidogenic tissuesAnti-Müllerian hormone as a marker of steroid and gonadotropin action in the testis of children and adolescents with disorders of the gonadal axisAnalyzing the coordinated gene network underlying temperature-dependent sex determination in reptilesDax1 antagonizes Sry action in mammalian sex determinationEliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine developmentc-Krox binds to several sites in the promoter of both mouse type I collagen genes. Structure/function study and developmental expression analysisA recurrent p.Arg92Trp variant in steroidogenic factor-1 (NR5A1) can act as a molecular switch in human sex developmentNR5A1 is a novel disease gene for 46,XX testicular and ovotesticular disorders of sex developmentImpaired follicle development and infertility in female mice lacking steroidogenic factor 1 in ovarian granulosa cells.Conditional deletion of the retinoblastoma (Rb) gene in ovarian granulosa cells leads to premature ovarian failure.Sex determination in the chicken embryo.Effective transcription factor binding site prediction using a combination of optimization, a genetic algorithm and discriminant analysis to capture distant interactions.Human sex determination.Mammalian sex determination: joining pieces of the genetic puzzle.New NR5A1 mutations and phenotypic variations of gonadal dysgenesis.New solutions to an ancient riddle: defining the differences between Adam and Eve.Global gene expression in the human fetal testis and ovaryNuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1Sex determination and the Y chromosome.SRY interacts with and negatively regulates androgen receptor transcriptional activity.The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation.X-linked adrenal hypoplasia congenita is caused by abnormal nuclear localization of the DAX-1 protein.Molecular genetics of Müllerian duct formation, regression and differentiationDual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner.Sox9 transactivation and testicular expression of a novel human gene, KIAA0800.Müllerian inhibiting substance/anti-Müllerian hormone: A novel treatment for gynecologic tumorsDisorders of sex development: new genes, new concepts.Transcriptional regulation of early oogenesis: in search of masters.Sex, genes, and heat: triggers of diversity.Anti-Müllerian hormone in disorders of sex determination and differentiation.
P2860
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P2860
Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: a link to the sex determination cascade
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年学术文章
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1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
name
Nuclear receptor steroidogenic ...... the sex determination cascade
@ast
Nuclear receptor steroidogenic ...... the sex determination cascade
@en
Nuclear receptor steroidogenic ...... the sex determination cascade
@en-gb
Nuclear receptor steroidogenic ...... the sex determination cascade
@nl
type
label
Nuclear receptor steroidogenic ...... the sex determination cascade
@ast
Nuclear receptor steroidogenic ...... the sex determination cascade
@en
Nuclear receptor steroidogenic ...... the sex determination cascade
@en-gb
Nuclear receptor steroidogenic ...... the sex determination cascade
@nl
prefLabel
Nuclear receptor steroidogenic ...... the sex determination cascade
@ast
Nuclear receptor steroidogenic ...... the sex determination cascade
@en
Nuclear receptor steroidogenic ...... the sex determination cascade
@en-gb
Nuclear receptor steroidogenic ...... the sex determination cascade
@nl
P2093
P921
P3181
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P1476
Nuclear receptor steroidogenic ...... the sex determination cascade
@en
P2093
P304
P3181
P356
10.1016/0092-8674(94)90050-7
P407
P577
1994-06-03T00:00:00Z