SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
about
MYBBP1A suppresses breast cancer tumorigenesis by enhancing the p53 dependent anoikisTargeting LKB1 in cancer - exposing and exploiting vulnerabilitiesEvaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic PotentialLKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer.hHSS1: a novel secreted factor and suppressor of glioma growth located at chromosome 19q13.33.Contribution of p53 to metastasis.Making sense of cancer genomic data.The Par3-like polarity protein Par3L is essential for mammary stem cell maintenance.Gene expression of the tumour suppressor LKB1 is mediated by Sp1, NF-Y and FOXO transcription factorsLKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer.FOXO3 is a glucocorticoid receptor target and regulates LKB1 and its own expression based on cellular AMP levels via a positive autoregulatory loop.Alternative cell death mechanisms in development and beyond.Loss of LKB1 in high-grade endometrial carcinoma: LKB1 is a novel transcriptional target of p53.Salt-inducible kinase 1 (SIK1) is induced by gastrin and inhibits migration of gastric adenocarcinoma cells.MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cellsA pathway for the control of anoikis sensitivity by E-cadherin and epithelial-to-mesenchymal transition.Understanding micrometastatic disease and Anoikis resistance in ewing family of tumors and osteosarcoma.The role of the basal stem cell of the human breast in normal development and cancer.LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.Salt-inducible kinase 1 regulates E-cadherin expression and intercellular junction stability.Metformin impairs the growth of liver kinase B1-intact cervical cancer cells.Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways.Supervillin-mediated suppression of p53 protein enhances cell survival.Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis.LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion.LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanomaThe LKB1 tumor suppressor differentially affects anchorage independent growth of HPV positive cervical cancer cell linesSIK2 Restricts Autophagic Flux To Support Triple-Negative Breast Cancer Survival.Targeting the LKB1 tumor suppressor.MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis.Live free or die: tales of homeless (cells) in cancer.LKB1 regulated pathways in lung cancer invasion and metastasis.The LKB1 complex-AMPK pathway: the tree that hides the forestTowards systematic functional characterization of cancer genomes.AMPK: a contextual oncogene or tumor suppressor?Integration of autophagy and anoikis resistance in solid tumors.Identification of differentially expressed genes through RNA sequencing in goats (Capra hircus) at different postnatal stages.The diverse oncogenic and tumor suppressor roles of salt-inducible kinase (SIK) in cancer.Attenuated LKB1-SIK1 signaling promotes epithelial-mesenchymal transition and radioresistance of non-small cell lung cancer cells
P2860
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P2860
SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
description
2009 nî lūn-bûn
@nan
2009 թուականին հրատարակուած գիտական յօդուած
@hyw
2009 թվականին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
@ast
SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
@en
SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
@en-gb
SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
@nl
type
label
SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
@ast
SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
@en
SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
@en-gb
SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
@nl
prefLabel
SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
@ast
SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
@en
SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
@en-gb
SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
@nl
P2093
P2860
P921
P3181
P1433
P1476
SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
@en
P2093
Alexander Miron
Andrea L Richardson
Hailing Cheng
J Dirk Iglehart
Jean J Zhao
Ole V Gjoerup
Stephanie Santiago
Victoria Garbitt
P2860
P3181
P356
10.1126/SCISIGNAL.2000369
P407
P577
2009-01-01T00:00:00Z