Targeting LKB1 in cancer - exposing and exploiting vulnerabilities - Test2 - elhamkhani - TriplyDB

Targeting LKB1 in cancer - exposing and exploiting vulnerabilities

Targeting LKB1 in cancer - exposing and exploiting vulnerabilities

http://www.wikidata.org/entity/Q26801412

about

Evidence of cancer-promoting roles for AMPK and related kinases Downregulation of LKB1 promotes tumor progression and predicts unfavorable prognosis in patients with glioma.The Liver Circadian Clock Modulates Biochemical and Physiological Responses to Metformin.Functional characterization of AMP-activated protein kinase signaling in tumorigenesis.Hereditary breast and ovarian cancer: new genes in confined pathways.Metabolic rewiring in mutant Kras lung cancer.Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas.Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling.YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting.

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Targeting LKB1 in cancer - exposing and exploiting vulnerabilities

http://www.wikidata.org/entity/Q26801412

description

2015 nî lūn-bûn

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2015 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի օգոստոսին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Targeting LKB1 in cancer - exposing and exploiting vulnerabilities

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Targeting LKB1 in cancer - exposing and exploiting vulnerabilities

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Targeting LKB1 in cancer - exposing and exploiting vulnerabilities

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type

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Targeting LKB1 in cancer - exposing and exploiting vulnerabilities

@ast

Targeting LKB1 in cancer - exposing and exploiting vulnerabilities

@en

Targeting LKB1 in cancer - exposing and exploiting vulnerabilities

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prefLabel

Targeting LKB1 in cancer - exposing and exploiting vulnerabilities

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Targeting LKB1 in cancer - exposing and exploiting vulnerabilities

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Targeting LKB1 in cancer - exposing and exploiting vulnerabilities

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Targeting LKB1 in cancer - exposing and exploiting vulnerabilities

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D B Shackelford

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M Momcilovic

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Creative Commons Attribution 4.0 International

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer

Structure of mammalian AMPK and its regulation by ADP

SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis

Cloning and characterization of two human polyspecific organic cation transporters

AMPK phosphorylation of raptor mediates a metabolic checkpoint

ARK5 is a tumor invasion-associated factor downstream of Akt signaling

Efficacy and safety of sirolimus in lymphangioleiomyomatosis.

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