MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis
about
A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegiaThe overexpression of MCPH1 inhibits cell growth through regulating cell cycle-related proteins and activating cytochrome c-caspase 3 signaling in cervical cancerE2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferasesEstablishment of a mouse model with misregulated chromosome condensation due to defective Mcph1 functionMCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathwayDNA IR-Double Strand Breaks (DSBs) and cellular response via ATMMCPH1: a window into brain development and evolution.BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice.Primary microcephaly: do all roads lead to Rome?Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1BPathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling.Primary microcephaly gene MCPH1 shows a novel molecular biomarker of human renal carcinoma and is regulated by miR-27a.The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex.DNA damage signals through differentially modified E2F1 molecules to induce apoptosis.A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells.Primary microcephaly gene MCPH1 shows signatures of tumor suppressors and is regulated by miR-27a in oral squamous cell carcinoma.Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapyMCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II.Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) SignalingFunctional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans.A high-throughput assay to identify modifiers of premature chromosome condensation.Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse modelChromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment.RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expressionTranscriptional and nontranscriptional functions of E2F1 in response to DNA damage.BRIT1 regulates p53 stability and functions as a tumor suppressor in breast cancer.14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response.The linkage of chromatin remodeling to genome maintenance: contribution from a human disease gene BRIT1/MCPH1Importin β-dependent nuclear import of TopBP1 in ATR-Chk1 checkpoint in Xenopus egg extracts.Molecular and cellular basis of autosomal recessive primary microcephaly.The DNA damage response molecule MCPH1 in brain development and beyond.NEDDylation controls the target specificity of E2F1 and apoptosis induction.MCPH1/BRIT1 limits ionizing radiation-induced centrosome amplification.ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination.MCPH1 maintains long-term epigenetic silencing of ANGPT2 in chronic lymphocytic leukemia.ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of histone deacetylase 1.Identification and functional characterization of a primate-specific E2F1 binding motif regulating MCPH1 expression.Overexpression of MCPH1 inhibits uncontrolled cell growth by promoting cell apoptosis and arresting the cell cycle in S and G2/M phase in lung cancer cellsMicrocephalin is a new novel prognostic indicator in breast cancer associated with BRCA1 inactivation.The E3 ubiquitin ligase APC/CCdh1 degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis.
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P2860
MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
MCPH1/BRIT1 cooperates with E2 ...... oint, DNA repair and apoptosis
@ast
MCPH1/BRIT1 cooperates with E2 ...... oint, DNA repair and apoptosis
@en
MCPH1/BRIT1 cooperates with E2 ...... oint, DNA repair and apoptosis
@en-gb
MCPH1/BRIT1 cooperates with E2 ...... oint, DNA repair and apoptosis
@nl
type
label
MCPH1/BRIT1 cooperates with E2 ...... oint, DNA repair and apoptosis
@ast
MCPH1/BRIT1 cooperates with E2 ...... oint, DNA repair and apoptosis
@en
MCPH1/BRIT1 cooperates with E2 ...... oint, DNA repair and apoptosis
@en-gb
MCPH1/BRIT1 cooperates with E2 ...... oint, DNA repair and apoptosis
@nl
prefLabel
MCPH1/BRIT1 cooperates with E2 ...... oint, DNA repair and apoptosis
@ast
MCPH1/BRIT1 cooperates with E2 ...... oint, DNA repair and apoptosis
@en
MCPH1/BRIT1 cooperates with E2 ...... oint, DNA repair and apoptosis
@en-gb
MCPH1/BRIT1 cooperates with E2 ...... oint, DNA repair and apoptosis
@nl
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MCPH1/BRIT1 cooperates with E2 ...... oint, DNA repair and apoptosis
@en
P2093
Fang-Tsyr Lin
Shan-Zhong Yang
Weei-Chin Lin
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P304
P356
10.1038/EMBOR.2008.128
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P577
2008-09-01T00:00:00Z