BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly.
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MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosisMutation in PHC1 implicates chromatin remodeling in primary microcephaly pathogenesisThe overexpression of MCPH1 inhibits cell growth through regulating cell cycle-related proteins and activating cytochrome c-caspase 3 signaling in cervical cancerThe ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair responseBRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolutionEstablishment of a mouse model with misregulated chromosome condensation due to defective Mcph1 functionA Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome CondensationDual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1Molecular Basis for the Association of Microcephalin (MCPH1) Protein with the Cell Division Cycle Protein 27 (Cdc27) Subunit of the Anaphase-promoting ComplexRoles of Chk1 in cell biology and cancer therapyMCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathwayVIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signalingMcph1-deficient mice reveal a role for MCPH1 in otitis mediaPhylogeny and adaptive evolution of the brain-development gene microcephalin (MCPH1) in cetaceansDifferential regulation of centrosome integrity by DNA damage response proteins.Viral regulation of aquaporin 4, connexin 43, microcephalin and nucleolinRole of BRCA1 in brain development.Positive selection on the nonhomologous end-joining factor Cernunnos-XLF in the human lineageBRIT1 regulates early DNA damage response, chromosomal integrity, and cancerPreviously described sequence variant in CDK5RAP2 gene in a Pakistani family with autosomal recessive primary microcephaly.MCPH1: a window into brain development and evolution.Genetics and biology of microcephaly and lissencephalyBRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice.Deregulation of microcephalin and ASPM expression are correlated with epithelial ovarian cancer progression.Small organelle, big responsibility: the role of centrosomes in development and disease.Primary microcephaly gene MCPH1 shows a novel molecular biomarker of human renal carcinoma and is regulated by miR-27a.The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex.Mutations in WDR62, encoding a centrosomal and nuclear protein, in Indian primary microcephaly families with cortical malformations.A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells.The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.Antineoplastic effects of α-santalol on estrogen receptor-positive and estrogen receptor-negative breast cancer cells through cell cycle arrest at G2/M phase and induction of apoptosis.Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) SignalingThe centrosome and its duplication cycleSET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensationDNA damage and breast cancerBRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1.DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cellsChromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment.The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 ComplexAtrazine Triggers DNA Damage Response and Induces DNA Double-Strand Breaks in MCF-10A Cells.
P2860
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P2860
BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly.
description
2005 nî lūn-bûn
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2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年學術文章
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BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.
@ast
BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.
@en
BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.
@nl
type
label
BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.
@ast
BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.
@en
BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.
@nl
prefLabel
BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.
@ast
BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.
@en
BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.
@nl
P2093
P2860
P356
P1476
BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.
@en
P2093
Shiaw-Yih Lin
Stephen J Elledge
Zhi-Xiang Xu
P2860
P304
15105-15109
P356
10.1073/PNAS.0507722102
P407
P577
2005-10-10T00:00:00Z