Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication
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Nuclease activity of Saccharomyces cerevisiae Dna2 inhibits its potent DNA helicase activity.Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrityAn evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic developmentAn extended network of genomic maintenance in the archaeon Pyrococcus abyssi highlights unexpected associations between eucaryotic homologsThe DNA2 nuclease/helicase is an estrogen-dependent gene mutated in breast and ovarian cancersDNA2 drives processing and restart of reversed replication forks in human cells.DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining.The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replicationYet another job for Dna2: Checkpoint activation.A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to ChemotherapyDNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network.DNA double-strand breaks with 5' adducts are efficiently channeled to the DNA2-mediated resection pathway.Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases.PCNA promotes processive DNA end resection by Exo1.Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1.Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1.The Intra-S Checkpoint Responses to DNA Damage.Mitochondrial DNA maintenance: an appraisal.Preventing over-resection by DNA2 helicase/nuclease suppresses repair defects in Fanconi anemia cells.DNA2-An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein?Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells.The motor activity of DNA2 functions as an ssDNA translocase to promote DNA end resection.Dna2 initiates resection at clean DNA double-strand breaks.Rad9/53BP1 protects stalled replication forks from degradation in Mec1/ATR-defective cells.hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability.
P2860
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P2860
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication
@ast
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication
@en
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication
@en-gb
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication
@nl
type
label
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication
@ast
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication
@en
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication
@en-gb
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication
@nl
prefLabel
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication
@ast
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication
@en
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication
@en-gb
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication
@nl
P2093
P2860
P921
P3181
P356
P1476
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication
@en
P2093
Benjamin Dao
Hayley R Moore
Helen Piwnica-Worms
Judith L Campbell
Julien P Duxin
Kenneth Karanja
Raymond J Monnat
Sheila A Stewart
Yuchi Honaker
P2860
P304
P3181
P356
10.1074/JBC.M112.359018
P407
P5008
P577
2012-06-22T00:00:00Z