Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase
about
Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseThe TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathwaysPolyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligasesThe RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERADDefining human ERAD networks through an integrative mapping strategyA ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradationSterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavageCYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligasesMembrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorptionUSP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradationRequirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surfaceThe activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding siteProteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysinesJuxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasisE2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell systemDiversity of degradation signals in the ubiquitin-proteasome systemUnsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination stepArmand-Frappier Outstanding Student Award--The emerging role of 25-hydroxycholesterol in innate immunityRoad to ruin: targeting proteins for degradation in the endoplasmic reticulumDual functions of Insig proteins in cholesterol homeostasisUbiquitin ligases in cholesterol metabolismPromiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin ChainsDeterminants of RING-E2 fidelity for Hrd1p, a membrane-anchored ubiquitin ligase.INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteinsFive Questions (with their Answers) on ER-Associated DegradationInsig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienolsThe role of a novel p97/valosin-containing protein-interacting motif of gp78 in endoplasmic reticulum-associated degradationTargeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein HomeostasisOrganizing principles of mammalian nonsense-mediated mRNA decayDimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chainsAnalysis of Schistosoma mansoni genes shared with Deuterostomia and with possible roles in host interactions.Improved cell survival in infarcted myocardium using a novel combination transmyocardial laser and cell delivery system.Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.The E3 ubiquitin ligases Hrd1 and gp78 bind to and promote cholera toxin retro-translocation.Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates.A role for KAI1 in promotion of cell proliferation and mammary gland hyperplasia by the gp78 ubiquitin ligase.Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, endoplasmic reticulum (ER)-associated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.Endoplasmic reticulum-associated degradation of Niemann-Pick C1: evidence for the role of heat shock proteins and identification of lysine residues that accept ubiquitin.Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets.
P2860
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P2860
Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Gp78, a membrane-anchored ubiq ...... gradation of HMG CoA reductase
@ast
Gp78, a membrane-anchored ubiq ...... gradation of HMG CoA reductase
@en
Gp78, a membrane-anchored ubiq ...... gradation of HMG CoA reductase
@en-gb
Gp78, a membrane-anchored ubiq ...... gradation of HMG CoA reductase
@nl
type
label
Gp78, a membrane-anchored ubiq ...... gradation of HMG CoA reductase
@ast
Gp78, a membrane-anchored ubiq ...... gradation of HMG CoA reductase
@en
Gp78, a membrane-anchored ubiq ...... gradation of HMG CoA reductase
@en-gb
Gp78, a membrane-anchored ubiq ...... gradation of HMG CoA reductase
@nl
prefLabel
Gp78, a membrane-anchored ubiq ...... gradation of HMG CoA reductase
@ast
Gp78, a membrane-anchored ubiq ...... gradation of HMG CoA reductase
@en
Gp78, a membrane-anchored ubiq ...... gradation of HMG CoA reductase
@en-gb
Gp78, a membrane-anchored ubiq ...... gradation of HMG CoA reductase
@nl
P921
P3181
P1433
P1476
Gp78, a membrane-anchored ubiq ...... gradation of HMG CoA reductase
@en
P2093
Navdar Sever
Russell A DeBose-Boyd
P304
P3181
P356
10.1016/J.MOLCEL.2005.08.009
P407
P577
2005-09-01T00:00:00Z