Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
about
Recent advances in the molecular genetics of type 2 diabetes mellitusPurinergic signalling in endocrine organsCyclic AMP dynamics in the pancreatic β-cellDrug repositioning for diabetes based on 'omics' data miningAdenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cellsThe Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsDisease gene identification by random walk on multigraphs merging heterogeneous genomic and phenotype data.Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes.Role of NAD(P)H oxidase in superoxide generation and endothelial dysfunction in Goto-Kakizaki (GK) rats as a model of nonobese NIDDM.Alpha2A-adrenergic receptor and eNOS genetic polymorphisms are associated with exercise muscle vasodilatation in apparently healthy individualsDetailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes.The transcriptome of human epicardial, mediastinal and subcutaneous adipose tissues in men with coronary artery diseaseGene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes.Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor.Repurposing cAMP-modulating medications to promote β-cell replication.Identification of a novel snake peptide toxin displaying high affinity and antagonist behaviour for the α2-adrenoceptors.Tempo and mode of gene duplication in mammalian ribosomal protein evolution.Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic isletsSubthreshold α₂-adrenergic activation counteracts glucagon-like peptide-1 potentiation of glucose-stimulated insulin secretion.Gender-related associations of genetic polymorphisms of α-adrenergic receptors, endothelial nitric oxide synthase and bradykinin B2 receptor with treadmill exercise test responses.Genetic variations in the α(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidineFunction and expression of sulfonylurea, adrenergic, and glucagon-like peptide 1 receptors in isolated porcine islets.Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies.Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.Metabolomic analysis of diet-induced type 2 diabetes using UPLC/MS integrated with pattern recognition approachGαi/o-coupled receptor signaling restricts pancreatic β-cell expansionGenetics of type 2 diabetes-pitfalls and possibilities.Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes.Protein interaction-based genome-wide analysis of incident coronary heart disease.GPCR mediated regulation of synaptic transmission.ADRA2A is involved in neuro-endocrine regulation of bone resorption.Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.Diversity Oriented Synthesis: Concise Entry to Novel Derivatives of Yohimbine and Corynanthe Alkaloids.Alpha2A adrenergic receptor genetic variation contributes to hyperglycemia after myocardial infarctionPancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational AnalysisEvolving insights regarding mechanisms for the inhibition of insulin release by norepinephrine and heterotrimeric G proteins.Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes.Leucine stimulates insulin secretion via down-regulation of surface expression of adrenergic α2A receptor through the mTOR (mammalian target of rapamycin) pathway: implication in new-onset diabetes in renal transplantationTranscriptional Regulation of the Pancreatic Islet: Implications for Islet Function.
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P2860
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
@ast
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
@en
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
@en-gb
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
@nl
type
label
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
@ast
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
@en
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
@en-gb
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
@nl
prefLabel
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
@ast
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
@en
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
@en-gb
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
@nl
P2093
P2860
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Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
@en
P2093
Anders H Rosengren
Charlotte Granhall
Dai-Qing Li
Damon Tojjar
Erik Renström
Holger Luthman
Ramunas Jokubka
Vini Nagaraj
P2860
P304
P3181
P356
10.1126/SCIENCE.1176827
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P50
P577
2010-01-08T00:00:00Z