Interaction of the Flt-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositol 3-kinase. Mapping of a novel site involved in binding
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Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase bindingStructure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinaseThe Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cellsVascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cellsTwo distinct intracytoplasmic regions of the T-cell adhesion molecule CD28 participate in phosphatidylinositol 3-kinase associationVascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxidePI3K/PTEN signaling in angiogenesis and tumorigenesisThe Role of PTEN in Tumor AngiogenesisQuercetin-4'-O-β-D-glucopyranoside (QODG) inhibits angiogenesis by suppressing VEGFR2-mediated signaling in zebrafish and endothelial cellsTyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and AktVascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinaseIdentification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing moleculesModulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1.Growth factor signaling pathways in vascular development.Vascular endothelial growth factor receptor 1 contributes to Escherichia coli K1 invasion of human brain microvascular endothelial cells through the phosphatidylinositol 3-kinase/Akt signaling pathway.VEGFR1 (Flt-1+/-) gene knockout leads to the disruption of VEGF-mediated signaling through the nitric oxide/heme oxygenase pathway in ischemic preconditioned myocardium.Angiogenesis: now and then.The role of VEGF receptors in angiogenesis; complex partnershipsThe effect of vascular endothelial growth factor in the progression of bladder cancer and diabetic retinopathy.Chimeric VEGFRs are activated by a small-molecule dimerizer and mediate downstream signalling cascades in endothelial cells.Activation of receptor-mediated angiogenesis and signaling pathways after VEGF administration in fetal rat CNS explants.The type 2 vascular endothelial growth factor receptor recruits insulin receptor substrate-1 in its signalling pathway.Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration.RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3K/Akt pathway.A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migrationPhosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase.VEGF(165) requires extracellular matrix components to induce mitogenic effects and migratory response in breast cancer cells.Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation.Attenuation of the exercise-induced increase in skeletal muscle Flt-1 mRNA by nitric oxide synthase inhibition.Structure and function of vascular endothelial growth factor and its receptor system.
P2860
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P2860
Interaction of the Flt-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositol 3-kinase. Mapping of a novel site involved in binding
description
1995 nî lūn-bûn
@nan
1995 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Interaction of the Flt-1 tyros ...... novel site involved in binding
@ast
Interaction of the Flt-1 tyros ...... novel site involved in binding
@en
Interaction of the Flt-1 tyros ...... novel site involved in binding
@en-gb
Interaction of the Flt-1 tyros ...... novel site involved in binding
@nl
type
label
Interaction of the Flt-1 tyros ...... novel site involved in binding
@ast
Interaction of the Flt-1 tyros ...... novel site involved in binding
@en
Interaction of the Flt-1 tyros ...... novel site involved in binding
@en-gb
Interaction of the Flt-1 tyros ...... novel site involved in binding
@nl
prefLabel
Interaction of the Flt-1 tyros ...... novel site involved in binding
@ast
Interaction of the Flt-1 tyros ...... novel site involved in binding
@en
Interaction of the Flt-1 tyros ...... novel site involved in binding
@en-gb
Interaction of the Flt-1 tyros ...... novel site involved in binding
@nl
P2093
P2860
P356
P1476
Interaction of the Flt-1 tyros ...... novel site involved in binding
@en
P2093
M N Waxham
P M Arrate
S A Cunningham
P2860
P304
P356
10.1074/JBC.270.35.20254
P407
P577
1995-09-01T00:00:00Z