Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules
about
Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular endothelial cell growth factor (VEGF) receptor mRNAs by VEGFDirect identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase bindingPhosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGFVEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis.The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cellsThe cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysisp21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migrationQuercetin-4'-O-β-D-glucopyranoside (QODG) inhibits angiogenesis by suppressing VEGFR2-mediated signaling in zebrafish and endothelial cellsBlood vessels as targets in tumor therapyNck adapter proteins: functional versatility in T cellsSequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position.Prediction of phosphotyrosine signaling networks using a scoring matrix-assisted ligand identification approach.Molecular diversity of VEGF-A as a regulator of its biological activity.Vascular endothelial growth factor receptor family genes: when did the three genes phylogenetically segregate?Cell type- and tumor zone-specific expression of pVEGFR-1 and its ligands influence colon cancer metastasis.The role of VEGF receptors in angiogenesis; complex partnershipsNovel roles of Src in cancer cell epithelial-to-mesenchymal transition, vascular permeability, microinvasion and metastasis.Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis.New insights into molecular mechanisms of diabetic kidney disease.Unlocking Doors without Keys: Activation of Src by Truncated C-terminal Intracellular Receptor Tyrosine Kinases Lacking Tyrosine Kinase Activity.Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein.A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migrationVascular endothelial cell growth factor activates CRE-binding protein by signaling through the KDR receptor tyrosine kinase.Effect of antiangiogenic therapy on tumor growth, vasculature and kinase activity in basal- and luminal-like breast cancer xenografts.A novel kinase mutation in VEGFR-1 predisposes its αC-helix/activation loop towards allosteric activation: Atomic insights from protein simulation.A novel snake venom vascular endothelial growth factor (VEGF) predominantly induces vascular permeability through preferential signaling via VEGF receptor-1.Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF.Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants.NCK and PAK participate in the signaling pathway by which vascular endothelial growth factor stimulates the assembly of focal adhesions.Blood vessel anastomosis is spatially regulated by Flt1 during angiogenesis.VEGFA;B;PLGF bind to VEGFR1 leading to receptor dimerization
P2860
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P2860
Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules
description
1998 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1998
@ast
im September 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/09/04)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/09/04)
@nl
наукова стаття, опублікована у вересні 1998
@uk
name
Identification of vascular end ...... H2 domain-containing molecules
@ast
Identification of vascular end ...... H2 domain-containing molecules
@en
Identification of vascular end ...... H2 domain-containing molecules
@nl
type
label
Identification of vascular end ...... H2 domain-containing molecules
@ast
Identification of vascular end ...... H2 domain-containing molecules
@en
Identification of vascular end ...... H2 domain-containing molecules
@nl
prefLabel
Identification of vascular end ...... H2 domain-containing molecules
@ast
Identification of vascular end ...... H2 domain-containing molecules
@en
Identification of vascular end ...... H2 domain-containing molecules
@nl
P2093
P2860
P356
P1476
Identification of vascular end ...... H2 domain-containing molecules
@en
P2093
C. Wernstedt
L. Claesson-Welsh
U. Engström
P2860
P304
23410–23418
P356
10.1074/JBC.273.36.23410
P407
P577
1998-09-04T00:00:00Z