G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets
about
A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to RhoThe ATP-gated P2X1 receptor plays a pivotal role in activation of aspirin-treated platelets by thrombin and epinephrineThe human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein familiesTyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-proteinCharacterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEFDistinct biochemical properties of the native members of the G12 G-protein subfamily. Characterization of G alpha 12 purified from rat brainPlatelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responsesThe emergence of proteinase-activated receptor-2 as a novel target for the treatment of inflammation-related CNS disordersPathophysiology of isoprostanes in the cardiovascular system: implications of isoprostane-mediated thromboxane A2 receptor activationHydrogen peroxide elicits constriction of skeletal muscle arterioles by activating the arachidonic acid pathwayRegulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinaseG protein heterotrimer Galpha13beta1gamma3 couples the angiotensin AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein myocytesThrombin-induced p38 mitogen-activated protein kinase activation is mediated by epidermal growth factor receptor transactivation pathwayIdentification of Galpha13 as one of the G-proteins that couple to human platelet thromboxane A2 receptorsDiscovering anti-platelet drug combinations with an integrated model of activator-inhibitor relationships, activator-activator synergies and inhibitor-inhibitor synergiesActivation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse plateletsInteraction of G alpha(12) with G alpha(13) and G alpha(q) signaling pathwaysPAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiologyThe human platelet ADP receptor activates Gi2 proteinsThrombin-induced endothelin-1 synthesis and secretion in retinal pigment epithelial cells is rho kinase dependentProtease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cellsEvolution of primary hemostasis in early vertebratesCyclooxygenase-dependent signalling: molecular events and consequences.Differential signaling by protease-activated receptors: implications for therapeutic targeting.G(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets.Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells.Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha12/13Thromboxane and the thromboxane receptor in cardiovascular disease.Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation.The role of heterotrimeric G proteins in platelet activation.Impact of vascular thromboxane prostanoid receptor activation on hemostasis, thrombosis, oxidative stress, and inflammation.Galpha12 and galpha13 are phosphorylated during platelet activation.The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain.Allosteric modulation of protease-activated receptor signaling.Dancing with multiple partners.Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets.Signaling during platelet adhesion and activationThrombin-induced glucose transport via Src-p38 MAPK pathway in vascular smooth muscle cellsRegulation of protease-activated receptor signaling by post-translational modifications.
P2860
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P2860
G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
G proteins of the G12 family a ...... n receptors in human platelets
@ast
G proteins of the G12 family a ...... n receptors in human platelets
@en
G proteins of the G12 family a ...... n receptors in human platelets
@en-gb
G proteins of the G12 family a ...... n receptors in human platelets
@nl
type
label
G proteins of the G12 family a ...... n receptors in human platelets
@ast
G proteins of the G12 family a ...... n receptors in human platelets
@en
G proteins of the G12 family a ...... n receptors in human platelets
@en-gb
G proteins of the G12 family a ...... n receptors in human platelets
@nl
prefLabel
G proteins of the G12 family a ...... n receptors in human platelets
@ast
G proteins of the G12 family a ...... n receptors in human platelets
@en
G proteins of the G12 family a ...... n receptors in human platelets
@en-gb
G proteins of the G12 family a ...... n receptors in human platelets
@nl
P2093
P2860
P356
P1476
G proteins of the G12 family a ...... n receptors in human platelets
@en
P2093
K L Laugwitz
P2860
P356
10.1073/PNAS.91.2.504
P407
P577
1994-01-18T00:00:00Z