Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations
about
Antimutator alleles of yeast DNA polymerase gamma modulate the balance between DNA synthesis and excisionMitochondrial DNA replication and disease: insights from DNA polymerase γ mutationsMitochondrial disorders of DNA polymerase γ dysfunction: from anatomic to molecular pathology diagnosisAlpers-Huttenlocher syndrome: the role of a multidisciplinary health care teamDNA polymerase γ and disease: what we have learned from yeastStructural insights into eukaryotic DNA replicationAlpers-Huttenlocher syndromeWatching the Bacteriophage N4 RNA Polymerase Transcription by Time-dependent Soak-trigger-freeze X-ray CrystallographyFunctional roles of the N- and C-terminal regions of the human mitochondrial single-stranded DNA-binding proteinA transposon-derived DNA polymerase from Entamoeba histolytica displays intrinsic strand displacement, processivity and lesion bypassPolg2 is essential for mammalian embryogenesis and is required for mtDNA maintenanceMMS exposure promotes increased MtDNA mutagenesis in the presence of replication-defective disease-associated DNA polymerase γ variantsAnalysis of Translesion DNA Synthesis by the Mitochondrial DNA Polymerase γEpilepsy due to mutations in the mitochondrial polymerase gamma (POLG) gene: A clinical and molecular genetic review.Pathogenicity in POLG syndromes: DNA polymerase gamma pathogenicity prediction server and database.How a homolog of high-fidelity replicases conducts mutagenic DNA synthesisMitochondrial DNA replication: a PrimPol perspective.Each monomer of the dimeric accessory protein for human mitochondrial DNA polymerase has a distinct role in conferring processivity.A mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial diseaseFunctional analysis of H. sapiens DNA polymerase gamma spacer mutation W748S with and without common variant E1143G.Mitochondrial genome maintenance in health and disease.mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiaeDefects of mitochondrial DNA replication.A single mutation in human mitochondrial DNA polymerase Pol gammaA affects both polymerization and proofreading activities of only the holoenzyme.Ribonucleotide discrimination and reverse transcription by the human mitochondrial DNA polymerase.C-terminal extension of the yeast mitochondrial DNA polymerase determines the balance between synthesis and degradation.Overexpression of DNA polymerase zeta reduces the mitochondrial mutability caused by pathological mutations in DNA polymerase gamma in yeast.Role of histidine 932 of the human mitochondrial DNA polymerase in nucleotide discrimination and inherited disease.Kinetic approaches to understanding the mechanisms of fidelity of the herpes simplex virus type 1 DNA polymeraseIdentification and characterization of a novel HIV-1 nucleotide-competing reverse transcriptase inhibitor series.Co-occurrence of four nucleotide changes associated with an adult mitochondrial ataxia phenotype.Mitochondrial DNA mutations in disease and agingPolymorphisms in DNA polymerase γ affect the mtDNA stability and the NRTI-induced mitochondrial toxicity in Saccharomyces cerevisiae.Biochemical analysis of human POLG2 variants associated with mitochondrial disease.Human DNA polymerase θ grasps the primer terminus to mediate DNA repairAlpers disease mutations in human DNA polymerase gamma cause catalytic defects in mitochondrial DNA replication by distinct mechanismsBiochemical analysis of the G517V POLG variant reveals wild-type like activity.Reduced stimulation of recombinant DNA polymerase γ and mitochondrial DNA (mtDNA) helicase by variants of mitochondrial single-stranded DNA-binding protein (mtSSB) correlates with defects in mtDNA replication in animal cells.Evolution of the metazoan mitochondrial replicase.Clustering of Alpers disease mutations and catalytic defects in biochemical variants reveal new features of molecular mechanism of the human mitochondrial replicase, Pol γ.
P2860
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P2860
Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structural insight into proces ...... e-related polymerase mutations
@ast
Structural insight into proces ...... e-related polymerase mutations
@en
Structural insight into proces ...... e-related polymerase mutations
@en-gb
Structural insight into proces ...... e-related polymerase mutations
@nl
type
label
Structural insight into proces ...... e-related polymerase mutations
@ast
Structural insight into proces ...... e-related polymerase mutations
@en
Structural insight into proces ...... e-related polymerase mutations
@en-gb
Structural insight into proces ...... e-related polymerase mutations
@nl
altLabel
Structural Insight into Proces ...... e-Related Polymerase Mutations
@en
prefLabel
Structural insight into proces ...... e-related polymerase mutations
@ast
Structural insight into proces ...... e-related polymerase mutations
@en
Structural insight into proces ...... e-related polymerase mutations
@en-gb
Structural insight into proces ...... e-related polymerase mutations
@nl
P2093
P2860
P921
P3181
P1433
P1476
Structural insight into proces ...... e-related polymerase mutations
@en
P2093
W Dexter Kennedy
Y Whitney Yin
Young-Sam Lee
P2860
P304
P3181
P356
10.1016/J.CELL.2009.07.050
P407
P577
2009-10-16T00:00:00Z