Human DNA polymerase θ grasps the primer terminus to mediate DNA repair - Test2 - elhamkhani - TriplyDB

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

http://www.wikidata.org/entity/Q35269686

about

DNA polymerase θ (POLQ), double-strand break repair, and cancer DNA Polymerase θ: A Unique Multifunctional End-Joining Machine Noncanonical views of homology-directed DNA repair Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair Error-Prone Repair of DNA Double-Strand Breaks.Linking DNA polymerase theta structure and function in health and disease Repair Pathway Choices and Consequences at the Double-Strand Break Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells.DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks.Regulation of Single-Strand Annealing and its Role in Genome Maintenance.Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.Mutagenic consequences of a single G-quadruplex demonstrate mitotic inheritance of DNA replication fork barriers.Expression and Structural Analyses of Human DNA Polymerase θ (POLQ).Polθ helicase: drive or reverse.Secondary structure forming sequences drive SD-MMEJ repair of DNA double-strand breaks.Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance.Family A and B DNA Polymerases in Cancer: Opportunities for Therapeutic Interventions.Mutational signatures of non-homologous and polymerase theta-mediated end-joining in embryonic stem cells.DNA polymerase beta participates in DNA End-joining.The helicase domain of Polθ counteracts RPA to promote alt-NHEJ.Plant organellar DNA polymerases are replicative and translesion DNA synthesis polymerases.In Vitro Bypass of Thymidine Glycol by DNA Polymerase θ Forms Sequence-Dependent Frameshift Mutations.The A-Rule and Deletion Formation During Abasic and Oxidized Abasic Site Bypass by DNA Polymerase θ.Translesion and Repair DNA Polymerases: Diverse Structure and Mechanism.Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.Structures of human DNA polymerases ν and θ expose their end game.

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Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

http://www.wikidata.org/entity/Q35269686

description

2015 nî lūn-bûn

@nan

2015 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի մարտին հրատարակված գիտական հոդված

@hy

2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

name

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

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Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

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type

label

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

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Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

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prefLabel

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

@ast

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

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Nature Structural & Molecular Biology

P1476

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

@en

P2093

April M Averill

http://www.w3.org/2001/XMLSchema#string

Karl E Zahn

http://www.w3.org/2001/XMLSchema#string

P2860

POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells

Promiscuous DNA synthesis by human DNA polymerase θ

POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro

Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations

High-efficiency bypass of DNA damage by human DNA polymerase Q

Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation

Caught bending the A-rule: crystal structures of translesion DNA synthesis with a non-natural nucleotide

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304-311

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scholarly article

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10.1038/NSMB.2993

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4

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22

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Richard Dean Wood

Sylvie Doublié

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2015-03-16T00:00:00Z

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273637589

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25775267

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4385486

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