Group I and II mammalian PAKs have different modes of activation by Cdc42
about
Mouse Genetic Models of Human Brain DisordersGroup II p21-activated kinases as therapeutic targets in gastrointestinal cancerp21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophilsPAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesionAn in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrateSubstrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6Signaling, Regulation, and Specificity of the Type II p21-activated KinasesDesign, synthesis and biological evaluation of 1-phenanthryl-tetrahydroisoquinoline derivatives as novel p21-activated kinase 4 (PAK4) inhibitorsPAK6 targets to cell-cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escapeProtein kinase D-mediated phosphorylation at Ser99 regulates localization of p21-activated kinase 4Direct interaction between AR and PAK6 in androgen-stimulated PAK6 activationA PAK6-IQGAP1 complex promotes disassembly of cell-cell adhesionsPAK signalling during the development and progression of cancer3D structure analysis of PAKs: A clue to the rational design for affinity reagents and blockers.The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.PAK4 interacts with p85 alpha: implications for pancreatic cancer cell migrationRepublished: tracing PAKs from GI inflammation to cancerEntamoeba histolytica RacC selectively engages p21-activated kinase effectorsRho GTPases and regulation of cell migration and polarization in human corneal epithelial cells.The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity.Kinases as targets for chemical modulators: Structural aspects and their role in spermatogenesis.The PAKs come of age: Celebrating 18 years of discovery.PAK4 Methylation by SETD6 Promotes the Activation of the Wnt/β-Catenin Pathway.Recent advances in the development of p21-activated kinase inhibitorsP21 activated kinases: structure, regulation, and functions.Tracing PAKs from GI inflammation to cancer.Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro.The P21-activated kinase PAK4 is implicated in fatty-acid potentiation of insulin secretion downstream of free fatty acid receptor 1.Structure, biochemistry, and biology of PAK kinases.Functional cross-talk between Cdc42 and two downstream targets, Par6B and PAK4.Recent advances in methods to assess the activity of the kinome.PAK family kinases: Physiological roles and regulation.ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome.Promoting Glucose Transporter-4 Vesicle Trafficking along Cytoskeletal Tracks: PAK-Ing Them Out.CDC42 binds PAK4 via an extended GTPase-effector interface.PAK4 crystal structures suggest unusual kinase conformational movements.Advances in the 1-phenanthryl-tetrahydroisoquinoline series of PAK4 inhibitors: potent agents restrain tumor cell growth and invasion.Melanoma-associated mutants within the serine-rich domain of PAK5 direct kinase activity to mitogenic pathways.p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation
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P2860
Group I and II mammalian PAKs have different modes of activation by Cdc42
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Group I and II mammalian PAKs have different modes of activation by Cdc42
@ast
Group I and II mammalian PAKs have different modes of activation by Cdc42
@en
Group I and II mammalian PAKs have different modes of activation by Cdc42
@en-gb
Group I and II mammalian PAKs have different modes of activation by Cdc42
@nl
type
label
Group I and II mammalian PAKs have different modes of activation by Cdc42
@ast
Group I and II mammalian PAKs have different modes of activation by Cdc42
@en
Group I and II mammalian PAKs have different modes of activation by Cdc42
@en-gb
Group I and II mammalian PAKs have different modes of activation by Cdc42
@nl
prefLabel
Group I and II mammalian PAKs have different modes of activation by Cdc42
@ast
Group I and II mammalian PAKs have different modes of activation by Cdc42
@en
Group I and II mammalian PAKs have different modes of activation by Cdc42
@en-gb
Group I and II mammalian PAKs have different modes of activation by Cdc42
@nl
P2093
P2860
P3181
P356
P1433
P1476
Group I and II mammalian PAKs have different modes of activation by Cdc42
@en
P2093
Felicia Tay Pei Ling
Widyawilis Selamat
Yohendran Baskaran
Yuen-Wai Ng
P2860
P3181
P356
10.1038/EMBOR.2012.75
P407
P577
2012-07-01T00:00:00Z