Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
about
Structural evolution of the protein kinase-like superfamilyFunctional interaction between c-Abl and the p21-activated protein kinase gamma-PAKIntermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alphaProtein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASPStructure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding.CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerizationCharacterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamilyStructure of the human protein kinase MPSK1 reveals an atypical activation loop architecturePak1 and PIX regulate contact inhibition during epithelial wound healingConstitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynaminGroup I and II mammalian PAKs have different modes of activation by Cdc42VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of TiamPaxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathwayPAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin.Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic propertiesS338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3Oligomerization of DH domain is essential for Dbl-induced transformationGGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteinsGain-of-function mutations of ARHGAP31, a Cdc42/Rac1 GTPase regulator, cause syndromic cutis aplasia and limb anomaliesRegulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoformA hippocampal Cdk5 pathway regulates extinction of contextual fearP21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migrationp21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BADp21-activated kinase signaling in breast cancerGroup II p21-activated kinases as therapeutic targets in gastrointestinal cancerRegulation of small GTPases by GEFs, GAPs, and GDIsAn in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain.Cosolvent-induced transformation of a death domain tertiary structureParallel coiled-coil association of the RhoA-binding domain in Rho-kinaseMolecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1)Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKsBiochemical and Structural Characterization of the Pak1-LC8 InteractionTargeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium ComplexesStructural and mechanistic insights into Mps1 kinase activationThe Structure of the MAP2K MEK6 Reveals an Autoinhibitory DimerCrystal Structure of the Formin mDia1 in Autoinhibited ConformationThe assembly of a GTPase–kinase signalling complex by a bacterial catalytic scaffold
P2860
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P2860
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
description
2000 nî lūn-bûn
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2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
@ast
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
@en
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
@nl
type
label
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
@ast
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
@en
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
@nl
prefLabel
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
@ast
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
@en
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
@nl
P2093
P3181
P1433
P1476
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
@en
P2093
M C Parrini
S C Harrison
P304
P3181
P356
10.1016/S0092-8674(00)00043-X
P407
P577
2000-08-04T00:00:00Z