BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization
about
High incidence of somatic BAP1 alterations in sporadic malignant mesotheliomaHistone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUBRecognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complexThe deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1BAP1 is phosphorylated at serine 592 in S-phase following DNA damageGermline mutations in BAP1 predispose to melanocytic tumorsAn emerging model for BAP1's role in regulating cell cycle progressionHistone deacetylase inhibitors induce growth arrest and differentiation in uveal melanomaThe ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expressionGermline BAP1 mutations predispose to malignant mesotheliomaRegulation and cellular roles of ubiquitin-specific deubiquitinating enzymesRole of Deubiquitinating Enzymes in DNA RepairStabilization of an Unusual Salt Bridge in Ubiquitin by the Extra C-Terminal Domain of the Proteasome-Associated Deubiquitinase UCH37 as a Mechanism of Its Exo SpecificityPrognostic parameters in uveal melanoma and their association with BAP1 expression.Consensus report of the 2015 Weinman International Conference on MesotheliomaCytoplasmic expression of BAP1 as an independent prognostic biomarker for patients with gliomasBRCA1-associated protein 1 deficiency in lung adenocarcinoma predicts poor outcome and increased tumor invasionLatest developments in our understanding of the pathogenesis of mesothelioma and the design of targeted therapiesCombined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700sMolecular pathways: targeting mechanisms of asbestos and erionite carcinogenesis in mesotheliomaComprehensive review of BAP1 tumor predisposition syndrome with report of two new casesBAP1 hereditary cancer predisposition syndrome: a case report and review of literatureAdvanced computational biology methods identify molecular switches for malignancy in an EGF mouse model of liver cancerMolecular genetics of clear-cell renal cell carcinomaDeubiquitylation of deubiquitylasesBAP1, a tumor suppressor gene driving malignant mesothelioma.Nuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to VpxMAC induced ubiquitination and proteasomal degradation.Ambiguous melanocytic tumors with loss of 3p21.Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing.USP33, a new player in lung cancer, mediates Slit-Robo signaling.The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer.Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers.The genetics of uveal melanoma: an emerging framework for targeted therapyBAP1 loss defines a new class of renal cell carcinoma.Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testingO-GlcNAc signaling in cancer metabolism and epigeneticsA novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma.The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer.
P2860
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P2860
BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
BRCA1-associated protein-1 is ...... ivity and nuclear localization
@ast
BRCA1-associated protein-1 is ...... ivity and nuclear localization
@en
BRCA1-associated protein-1 is ...... ivity and nuclear localization
@en-gb
BRCA1-associated protein-1 is ...... ivity and nuclear localization
@nl
type
label
BRCA1-associated protein-1 is ...... ivity and nuclear localization
@ast
BRCA1-associated protein-1 is ...... ivity and nuclear localization
@en
BRCA1-associated protein-1 is ...... ivity and nuclear localization
@en-gb
BRCA1-associated protein-1 is ...... ivity and nuclear localization
@nl
prefLabel
BRCA1-associated protein-1 is ...... ivity and nuclear localization
@ast
BRCA1-associated protein-1 is ...... ivity and nuclear localization
@en
BRCA1-associated protein-1 is ...... ivity and nuclear localization
@en-gb
BRCA1-associated protein-1 is ...... ivity and nuclear localization
@nl
P2093
P2860
P3181
P1433
P1476
BRCA1-associated protein-1 is ...... ivity and nuclear localization
@en
P2093
Erwin G Van Meir
Karen H Ventii
Keith D Wilkinson
Kenneth L Friedrich
Mourad Tighiouart
Narra S Devi
Tatiana A Chernova
P2860
P304
P3181
P356
10.1158/0008-5472.CAN-08-0365
P407
P577
2008-09-01T00:00:00Z