Nuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to VpxMAC induced ubiquitination and proteasomal degradation.

Nuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to VpxMAC induced ubiquitination and proteasomal degradation.

Item
http://www.wikidata.org/entity/Q33903117
dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.Restriction of HIV-1 Requires the N-Terminal Region of MxB as a Capsid-Binding Motif but Not as a Nuclear Localization SignalSingle-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer.Karyopherin Alpha 2 Promotes the Inflammatory Response in Rat Pancreatic Acinar Cells Via Facilitating NF-κB Activation.Upregulation of nuclear transporter, Kpnβ1, contributes to accelerated cell proliferation- and cell adhesion-mediated drug resistance (CAM-DR) in diffuse large B-cell lymphoma.Degradation of SAMHD1 by Vpx Is Independent of Uncoating.G2/M cell cycle arrest correlates with primate lentiviral Vpr interaction with the SLX4 complex.Comparative interactomics for virus-human protein-protein interactions: DNA viruses versus RNA viruses.Roles of SAMHD1 in antiviral defense, autoimmunity and cancer.Effects of Inner Nuclear Membrane Proteins SUN1/UNC-84A and SUN2/UNC-84B on the Early Steps of HIV-1 Infection.A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans.An Importin Code in neuronal transport from synapse-to-nucleus?DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1.Insights from the Molecular Modelling and Docking Analysis of AIF-NLS complex to infer Nuclear Translocation of the Protein.
P2860

Nuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to VpxMAC induced ubiquitination and proteasomal degradation.

Item
http://www.wikidata.org/entity/Q33903117
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2014 nî lūn-bûn
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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2014 թվականի ապրիլին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
@wuu
name
Nuclear import of SAMHD1 is me ...... n and proteasomal degradation.
@ast
Nuclear import of SAMHD1 is me ...... n and proteasomal degradation.
@en
type
label
Nuclear import of SAMHD1 is me ...... n and proteasomal degradation.
@ast
Nuclear import of SAMHD1 is me ...... n and proteasomal degradation.
@en
prefLabel
Nuclear import of SAMHD1 is me ...... n and proteasomal degradation.
@ast
Nuclear import of SAMHD1 is me ...... n and proteasomal degradation.
@en
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P478
P50
P577
P5875
P6179
P698
P921
P932
P356
P1433
P1476
Nuclear import of SAMHD1 is me ...... n and proteasomal degradation.
@en
P2093
P2860
P2888
P304
P31
P356
P478
P50
P577
P5875
P6179
P698
P921
P932