Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
about
Function, regulation and pathological roles of the Gab/DOS docking proteinsStructural basis for recognition of the third SH3 domain of full-length R85 (R85FL)/ponsin by ataxin-7Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative mannerHistidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpLGAB2--a scaffolding protein in cancerOrder and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategiesEarly beginnings - the emergence of complex signaling systems and cell-to-cell communicationGrb2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner.Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).The proline-rich region of 18.5 kDa myelin basic protein binds to the SH3-domain of Fyn tyrosine kinase with the aid of an upstream segment to form a dynamic complex in vitro.Quantitative analysis by surface plasmon resonance of CD28 interaction with cytoplasmic adaptor molecules Grb2, Gads and p85 PI3K.GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner.Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screenA dynamic view of domain-motif interactions.Application of ring-closing metathesis to Grb2 SH3 domain-binding peptides.Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric controlSelf-organization and regulation of intrinsically disordered proteins with folded N-termini.Secondary structure, a missing component of sequence-based minimotif definitions.Conformational analysis of isolated domains of Helicobacter pylori CagA.Binding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms.Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retina.JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cellsSurvey of the year 2009: applications of isothermal titration calorimetry.What's in a loop?Receptor tyrosine kinase (RTK) signalling in the control of neural stem and progenitor cell (NSPC) development.Conformational recognition of an intrinsically disordered protein.The importance of intrinsic order in a disordered protein ligand.Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells.Reply to: "Only kinetics can prove conformational selection".Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2.Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.
P2860
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P2860
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
@ast
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
@en
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
@en-gb
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
@nl
type
label
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
@ast
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
@en
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
@en-gb
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
@nl
prefLabel
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
@ast
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
@en
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
@en-gb
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
@nl
P2093
P921
P1433
P1476
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
@en
P2093
Dhira Joshi
E Yvonne Jones
Marc Lewitzky
Maria Harkiolaki
Philip C Simister
Stephan M Feller
Theodora Tsirka
P304
P356
10.1016/J.STR.2009.03.017
P407
P577
2009-06-10T00:00:00Z