Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors
about
Cell signaling by receptor tyrosine kinasesStructural basis of receptor sharing by interleukin 17 cytokinesMolecular and Structural Insight into proNGF Engagement of p75NTR and SortilinCytokine Spatzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activationGeneration of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexesThe Under-Appreciated Promiscuity of the Epidermal Growth Factor Receptor FamilyCyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in miceConformational plasticity of proNGFAgrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK)Divergent roles of p75NTR and Trk receptors in BDNF's effects on dendritic spine density and morphologyThe protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiationSuppression of p75 neurotrophin receptor surface expression with intrabodies influences Bcl-xL mRNA expression and neurite outgrowth in PC12 cellsSingle cycle structure-based humanization of an anti-nerve growth factor therapeutic antibodyTaking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activityTargeting Neuroblastoma Cell Surface Proteins: Recommendations for Homology Modeling of hNET, ALK, and TrkBBayesian model predicts the response of axons to molecular gradients.Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activityFates of neurotrophins after retrograde axonal transport: phosphorylation of p75NTR is a sorting signal for delayed degradationActivation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimersNeurobiology of local and intercellular BDNF signaling.Cardiovascular actions of neurotrophinsMechanisms of activation of receptor tyrosine kinases: monomers or dimers.A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.Understanding proneurotrophin actions: Recent advances and challenges.Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.A monovalent agonist of TrkA tyrosine kinase receptors can be converted into a bivalent antagonist.The nerve growth factor signaling and its potential as therapeutic target for glaucomaIntranasal "painless" human Nerve Growth Factor [corrected] slows amyloid neurodegeneration and prevents memory deficits in App X PS1 miceOptimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression.Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.Chronic nerve growth factor exposure increases apoptosis in a model of in vitro induced conjunctival myofibroblastsNeurotrophin signaling and visceral hypersensitivityLigand-induced dynamics of neurotrophin receptors investigated by single-molecule imaging approaches.Association between p75 neurotrophin receptor gene expression and cell apoptosis in tissues surrounding hematomas in rat models of intracerebral hemorrhage.The structure of nerve growth factor in complex with lysophosphatidylinositol.Importance of interaction between nerve growth factor and α9β1 integrin in glial tumor angiogenesisAnti-apoptotic role and clinical relevance of neurotrophins in diffuse large B-cell lymphomasThe rabies virus glycoprotein receptor p75NTR is not essential for rabies virus infection.The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretaseRETRACTED: A mathematical model explains saturating axon guidance responses to molecular gradients.
P2860
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P2860
Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Structural and mechanistic ins ...... ith the TrkA and p75 receptors
@ast
Structural and mechanistic ins ...... ith the TrkA and p75 receptors
@en
Structural and mechanistic ins ...... ith the TrkA and p75 receptors
@en-gb
Structural and mechanistic ins ...... ith the TrkA and p75 receptors
@nl
type
label
Structural and mechanistic ins ...... ith the TrkA and p75 receptors
@ast
Structural and mechanistic ins ...... ith the TrkA and p75 receptors
@en
Structural and mechanistic ins ...... ith the TrkA and p75 receptors
@en-gb
Structural and mechanistic ins ...... ith the TrkA and p75 receptors
@nl
prefLabel
Structural and mechanistic ins ...... ith the TrkA and p75 receptors
@ast
Structural and mechanistic ins ...... ith the TrkA and p75 receptors
@en
Structural and mechanistic ins ...... ith the TrkA and p75 receptors
@en-gb
Structural and mechanistic ins ...... ith the TrkA and p75 receptors
@nl
P2093
P3181
P1433
P1476
Structural and mechanistic ins ...... ith the TrkA and p75 receptors
@en
P2093
Abhiram Dukipatti
Helen Blau
K Christopher Garcia
Tom Wehrman
Xiaolin He
P3181
P356
10.1016/J.NEURON.2006.09.034
P407
P577
2007-01-04T00:00:00Z