Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers
about
Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosisStructure and function of the intracellular region of the plexin-b1 transmembrane receptorRecent advances in understanding neurotrophin signalingA novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury.Molecular and Structural Insight into proNGF Engagement of p75NTR and SortilinStructural characterization of the self-association of the death domain of p75(NTR.)Myelin-associated glycoprotein modulates apoptosis of motoneurons during early postnatal development via NgR/p75(NTR) receptor-mediated activation of RhoA signaling pathwaysMultiple motifs regulate apical sorting of p75 via a mechanism that involves dimerization and higher-order oligomerization.Genetic control of programmed cell death during animal development.Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing.Mechanisms of activation of receptor tyrosine kinases: monomers or dimers.p75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17.Understanding proneurotrophin actions: Recent advances and challenges.Activation of transmembrane cell-surface receptors via a common mechanism? The "rotation model".BNN27, a 17-Spiroepoxy Steroid Derivative, Interacts With and Activates p75 Neurotrophin Receptor, Rescuing Cerebellar Granule Neurons from Apoptosis.Ligand-induced dynamics of neurotrophin receptors investigated by single-molecule imaging approaches.Heterodimerization of p45-p75 modulates p75 signaling: structural basis and mechanism of action.Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.Detection of p75NTR Trimers: Implications for Receptor Stoichiometry and Activation.Mapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosisThe effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretaseStructural basis of death domain signaling in the p75 neurotrophin receptorNerve growth factor in cancer cell death and survival.The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol DrinkingBax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes.p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells.Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR).Role of nerve growth factor (NGF) and its receptors in folliculogenesis.Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family MoleculesNeurotrophins and B-cell malignancies.The transmembrane domain of the p75 neurotrophin receptor stimulates phosphorylation of the TrkB tyrosine kinase receptor.Ligand-dependent responses of the silkworm prothoracicotropic hormone receptor, Torso, are maintained by unusual intermolecular disulfide bridges in the transmembrane region.Piecing it together: Unraveling the elusive structure-function relationship in single-pass membrane receptors.NMR Dynamics of Transmembrane and Intracellular Domains of p75NTR in Lipid-Protein Nanodiscs.Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells.Expression and purification of the p75 neurotrophin receptor transmembrane domain using a ketosteroid isomerase tag.Polar/Ionizable residues in transmembrane segments: effects on helix-helix packing.Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces death receptor 5 networks that are highly organized.Open and closed conformations of the isolated transmembrane domain of death receptor 5 support a new model of activation.Structural Basis of p75 Transmembrane Domain Dimerization.
P2860
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P2860
Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Activation of the p75 neurotro ...... ulphide-linked receptor dimers
@ast
Activation of the p75 neurotro ...... ulphide-linked receptor dimers
@en
type
label
Activation of the p75 neurotro ...... ulphide-linked receptor dimers
@ast
Activation of the p75 neurotro ...... ulphide-linked receptor dimers
@en
prefLabel
Activation of the p75 neurotro ...... ulphide-linked receptor dimers
@ast
Activation of the p75 neurotro ...... ulphide-linked receptor dimers
@en
P2093
P2860
P50
P1433
P1476
Activation of the p75 neurotro ...... ulphide-linked receptor dimers
@en
P2093
Anastasia Simi
Bruce D Carter
Carlos F Ibáñez
Esra Karaca
Peter J Verveer
Philippe I H Bastiaens
Rajappa S Kenchappa
Soyoung Choi
Wilma J Friedman
P2860
P356
10.1016/J.NEURON.2009.02.020
P407
P50
P577
2009-04-01T00:00:00Z