Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling
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Ten things you should know about protein kinases: IUPHAR Review 14Elucidation of Ligand-Dependent Modulation of Disorder-Order Transitions in the Oncoprotein MDM2Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapiesVirtual screening on an α-helix to β-strand switchable region of the FGFR2 extracellular domain revealed positive and negative modulators.Integration of signals along orthogonal axes of the vertebrate neural tube controls progenitor competence and increases cell diversityStructure-based virtual screening for drug discovery: principles, applications and recent advances.Binding cavities and druggability of intrinsically disordered proteins.Conformational Sampling and Binding Site Assessment of Suppression of Tumorigenicity 2 EctodomainConformational Selection and Induced Fit Mechanisms in the Binding of an Anticancer Drug to the c-Src KinaseThe cytoplasmic domain of the T-cell receptor zeta subunit does not form disordered dimers.API5 confers cancer stem cell-like properties through the FGF2-NANOG axis.Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancerAngiogenesis inhibitors in cancer therapy: mechanistic perspective on classification and treatment rationales.A theoretical view of protein dynamics.Approaches targeting the FGF-FGFR system: a review of the recent patent literature and associated advanced therapeutic agents.Emerging roles of FGF signaling in hepatocellular carcinoma.FGF receptor antagonism does not affect adipose tissue development in nutritionally induced obesity.Two strategies to engineer flexible loops for improved enzyme thermostability.API5 induces cisplatin resistance through FGFR signaling in human cancer cells.FGF-dependent metabolic control of vascular development.Multisystem altruistic metadynamics-Well-tempered variant.A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemia.Allosteric modulation as a unifying mechanism for receptor function and regulation.Allosteric targeting of receptor tyrosine kinases.[SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling].Design, synthesis and biological evaluation of 4-bromo-N-(3,5-dimethoxyphenyl)benzamide derivatives as novel FGFR1 inhibitors for treatment of non-small cell lung cancer.Insights into the mechanism of the PIK3CA E545K activating mutation using MD simulations
P2860
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P2860
Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling
description
2013 nî lūn-bûn
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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Molecular mechanism of SSR1281 ...... itor of FGF receptor signaling
@ast
Molecular mechanism of SSR1281 ...... itor of FGF receptor signaling
@en
Molecular mechanism of SSR1281 ...... itor of FGF receptor signaling
@en-gb
Molecular mechanism of SSR1281 ...... itor of FGF receptor signaling
@nl
type
label
Molecular mechanism of SSR1281 ...... itor of FGF receptor signaling
@ast
Molecular mechanism of SSR1281 ...... itor of FGF receptor signaling
@en
Molecular mechanism of SSR1281 ...... itor of FGF receptor signaling
@en-gb
Molecular mechanism of SSR1281 ...... itor of FGF receptor signaling
@nl
prefLabel
Molecular mechanism of SSR1281 ...... itor of FGF receptor signaling
@ast
Molecular mechanism of SSR1281 ...... itor of FGF receptor signaling
@en
Molecular mechanism of SSR1281 ...... itor of FGF receptor signaling
@en-gb
Molecular mechanism of SSR1281 ...... itor of FGF receptor signaling
@nl
P2093
P50
P3181
P1433
P1476
Molecular mechanism of SSR1281 ...... itor of FGF receptor signaling
@en
P2093
Chantal Alcouffe
Corentin Herbert
David Sibrac
Denis Kudlinzki
Françoise Bono
Frederic Rousseau
Gilbert Lassalle
Jean-Marc Herbert
Jean-Pascal Herault
P304
P3181
P356
10.1016/J.CCR.2013.02.018
P407
P50
P577
2013-04-15T00:00:00Z