The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers - Test2 - elhamkhani - TriplyDB

The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers

The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers

http://www.wikidata.org/entity/Q24339485

about

Epigenetic regulators and their impact on therapy in acute myeloid leukemia Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance New answers to old questions from genome-wide maps of DNA methylation in hematopoietic cells Next generation sequencing of acute myeloid leukemia: influencing prognosis.DNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic Disorders Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence Epigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis.DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling DNMT3a epigenetic program regulates the HIF-2α oxygen-sensing pathway and the cellular response to hypoxia.DNMT3A in haematological malignancies.Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells.Dynamic evolution of clonal epialleles revealed by methclone.Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition.Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.TET proteins and the control of cytosine demethylation in cancer.Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia Quantitative detection of DNMT3A R882H mutation in acute myeloid leukemia DNMT3A R882 Mutations Predict a Poor Prognosis in AML: A Meta-Analysis From 4474 Patients Loss of Dnmt3a and endogenous Kras(G12D/+) cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis The genomic landscape of juvenile myelomonocytic leukemia.P16-specific DNA methylation by engineered zinc finger methyltransferase inactivates gene transcription and promotes cancer metastasis.DNA methylation and hydroxymethylation in hematologic differentiation and transformation.PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia The Impact of DNA Methylation in Hematopoietic Malignancies.DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation.Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a.DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies.Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development.DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia Persistence of DNMT3A R882 mutations during remission does not adversely affect outcomes of patients with acute myeloid leukaemia.Genetic landscape of T- and NK-cell post-transplant lymphoproliferative disorders Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD).Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer DNA methyltransferases and their roles in tumorigenesis.Evaluation of DNMT3A genetic polymorphisms as outcome predictors in AML patients.Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model.

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P2860

The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers

http://www.wikidata.org/entity/Q24339485

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2014 nî lūn-bûn

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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2014 թվականի ապրիլին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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J.CCR.2014.02.010

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The R882H DNMT3A mutation asso ...... ility to form active tetramers

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Christopher A Miller

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David H Spencer

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Margaret A Young

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Matthew R Meyer

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Petra Erdmann-Gilmore

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R Reid Townsend

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Richard K Wilson

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Robert Fulton

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Tamara L Lamprecht

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Timothy J Ley

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P2860

Differential expression analysis for sequence count data

Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

Recurring mutations found by sequencing an acute myeloid leukemia genome

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

DNMT3A Mutations in Acute Myeloid Leukemia

Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia

Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia.

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4

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25

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David A Russler-Germain

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261033151

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identical protein binding

DNA methyltransferase 3 alpha

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