Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL
about
Crystal structure of the mouse interleukin-3 β-receptor: insights into interleukin-3 binding and receptor activationATP-Competitive MLKL Binders Have No Functional Impact on NecroptosisDistinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosisThe Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent mannerPseudokinases: update on their functions and evaluation as new drug targets.Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-bindingRegulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis?Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analysesA robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.The evolving world of pseudoenzymes: proteins, prejudice and zombiesRegulated cell death in AKI.Role of Intrinsic and Extrinsic Factors in the Regulation of the Mitotic Checkpoint Kinase Bub1.Analysis of the N-terminal region of human MLKL, as well as two distinct MLKL isoforms, reveals new insights into necroptotic cell deathHSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death.Flicking the molecular switch underlying MLKL-mediated necroptosis.Evolutionary divergence of the necroptosis effector MLKL.Ars Moriendi; the art of dying well - new insights into the molecular pathways of necroptotic cell death.Kinases and pseudokinases: lessons from RAF.Going for broke: targeting the human cancer pseudokinome.A tale of two domains - a structural perspective of the pseudokinase, MLKL.Nucleotide-binding mechanisms in pseudokinases.Necrosome core machinery: MLKL.Generation of small molecules to interfere with regulated necrosis.Insane in the membrane: a structural perspective of MLKL function in necroptosis.p190RhoGAP proteins contain pseudoGTPase domains.Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1.Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association.Characterization of Ligand Binding to Pseudokinases Using a Thermal Shift Assay.The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis.Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.
P2860
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P2860
Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL
description
2014 nî lūn-bûn
@nan
2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Insights into the evolution of ...... ctures of human and mouse MLKL
@ast
Insights into the evolution of ...... ctures of human and mouse MLKL
@en
Insights into the evolution of ...... ctures of human and mouse MLKL
@en-gb
Insights into the evolution of ...... ctures of human and mouse MLKL
@nl
type
label
Insights into the evolution of ...... ctures of human and mouse MLKL
@ast
Insights into the evolution of ...... ctures of human and mouse MLKL
@en
Insights into the evolution of ...... ctures of human and mouse MLKL
@en-gb
Insights into the evolution of ...... ctures of human and mouse MLKL
@nl
prefLabel
Insights into the evolution of ...... ctures of human and mouse MLKL
@ast
Insights into the evolution of ...... ctures of human and mouse MLKL
@en
Insights into the evolution of ...... ctures of human and mouse MLKL
@en-gb
Insights into the evolution of ...... ctures of human and mouse MLKL
@nl
P2093
P2860
P50
P921
P3181
P356
P1433
P1476
Insights into the evolution of ...... ctures of human and mouse MLKL
@en
P2093
Guillaume Lessene
Isabelle S Lucet
Joanne M Hildebrand
Maria C Tanzer
Peter E Czabotar
Pooja Sharma
Samuel N Young
Warren S Alexander
P2860
P304
P3181
P356
10.1042/BJ20131270
P407
P577
2014-02-01T00:00:00Z