ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor
about
STRAD pseudokinases regulate axogenesis and LKB1 stabilityMO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinasesStructure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activationA secretory kinase complex regulates extracellular protein phosphorylationInsights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKLMitotic exit and separation of mother and daughter cellsThe polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal AdhesionsGenomics, evolution, and crystal structure of a new family of bacterial spore kinasesA Conserved Non-canonical Motif in the Pseudoactive Site of the ROP5 Pseudokinase Domain Mediates Its Effect on Toxoplasma VirulenceNF45 dimerizes with NF90, Zfr and SPNR via a conserved domain that has a nucleotidyltransferase foldStructural insights into the activation of MST3 by MO25Structure of zebrafish MO25An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 PseudokinaseThe multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2α indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathwaySignalling scaffolds and local organization of cellular behaviourAnalysis of Jak2 catalytic function by peptide microarrays: the role of the JH2 domain and V617F mutationInvestigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activityThe Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent mannerStructural and biochemical insights into the activation mechanisms of germinal center kinase OSR1.Pseudokinases: update on their functions and evaluation as new drug targets.JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitorsStructure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-bindingSTRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and miceFission yeast germinal center (GC) kinase Ppk11 interacts with Pmo25 and plays an auxiliary role in concert with the morphogenesis Orb6 network (MOR) in cell morphogenesis.Receptor tyrosine kinases with intracellular pseudokinase domainsA robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.Kinase drug discovery--what's next in the field?The evolving world of pseudoenzymes: proteins, prejudice and zombiesBio-Zombie: the rise of pseudoenzymes in biology.Frontier of epilepsy research - mTOR signaling pathway.Cell cycle regulated interaction of a yeast Hippo kinase and its activator MO25/Hym1Biochemical, proteomic, structural, and thermodynamic characterizations of integrin-linked kinase (ILK): cross-validation of the pseudokinase.ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activationA novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3).Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).Structural Basis for the Non-catalytic Functions of Protein Kinases.From the research laboratory to the database: the Caenorhabditis elegans kinome in UniProtKBSkp2-dependent ubiquitination and activation of LKB1 is essential for cancer cell survival under energy stress.Pseudokinases-remnants of evolution or key allosteric regulators?
P2860
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P2860
ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
ATP and MO25α Regulate the Con ...... of the LKB1 Tumour Suppressor
@ast
ATP and MO25α Regulate the Con ...... of the LKB1 Tumour Suppressor
@en
ATP and MO25α Regulate the Con ...... of the LKB1 Tumour Suppressor
@en-gb
ATP and MO25α Regulate the Con ...... of the LKB1 Tumour Suppressor
@nl
type
label
ATP and MO25α Regulate the Con ...... of the LKB1 Tumour Suppressor
@ast
ATP and MO25α Regulate the Con ...... of the LKB1 Tumour Suppressor
@en
ATP and MO25α Regulate the Con ...... of the LKB1 Tumour Suppressor
@en-gb
ATP and MO25α Regulate the Con ...... of the LKB1 Tumour Suppressor
@nl
prefLabel
ATP and MO25α Regulate the Con ...... of the LKB1 Tumour Suppressor
@ast
ATP and MO25α Regulate the Con ...... of the LKB1 Tumour Suppressor
@en
ATP and MO25α Regulate the Con ...... of the LKB1 Tumour Suppressor
@en-gb
ATP and MO25α Regulate the Con ...... of the LKB1 Tumour Suppressor
@nl
P2093
P2860
P50
P3181
P1433
P1476
ATP and MO25α Regulate the Con ...... of the LKB1 Tumour Suppressor
@en
P2093
Daan M F van Aalten
Iva Navratilova
Simon Goldie
P2860
P304
P3181
P356
10.1371/JOURNAL.PBIO.1000126
P407
P577
2009-06-09T00:00:00Z