Genetic and biochemical analysis of p23 and ansamycin antibiotics in the function of Hsp90-dependent signaling proteins
about
In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysisAha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperoneChaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperonesLigand-independent activation of oestrogen receptor alpha by caveolin-1The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKRRole for Hsp90-associated cochaperone p23 in estrogen receptor signal transductionThe p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficaciesHigh levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistanceThe heat shock protein 90 of Plasmodium falciparum and antimalarial activity of its inhibitor, geldanamycinCNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90.Functional interactions between Hsp90 and the co-chaperones Cns1 and Cpr7 in Saccharomyces cerevisiae.Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast.Cns1 is an activator of the Ssa1 ATPase activity.The yeast Hsp110 family member, Sse1, is an Hsp90 cochaperone.The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone systemAntifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug actionIdentification and characterization of Harc, a novel Hsp90-associating relative of Cdc37Detection of changes in gene regulatory patterns, elicited by perturbations of the Hsp90 molecular chaperone complex, by visualizing multiple experiments with an animation.A role for the Hsp40 Ydj1 in repression of basal steroid receptor activity in yeastHsp90 nuclear accumulation in quiescence is linked to chaperone function and spore development in yeast.Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23.Hsp90 binds and regulates Gcn2, the ligand-inducible kinase of the alpha subunit of eukaryotic translation initiation factor 2 [corrected]Hsp104 interacts with Hsp90 cochaperones in respiring yeastMaturation of steroid receptors: an example of functional cooperation among molecular chaperones and their associated proteinsIn vitro reconstitution of functional hepadnavirus reverse transcriptase with cellular chaperone proteins.The Hsp90 cochaperone p23 is essential for perinatal survival.p23, a simple protein with complex activitiesLeishmania donovani P23 protects parasites against HSP90 inhibitor-mediated growth arrest.Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90The response to heat shock and oxidative stress in Saccharomyces cerevisiaeFused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents.The Cdc37 protein kinase-binding domain is sufficient for protein kinase activity and cell viability.Fungal heat-shock proteins in human disease.The heat shock protein 70 cochaperone YDJ1 is required for efficient membrane-specific flock house virus RNA replication complex assembly and function in Saccharomyces cerevisiaep23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activityEstrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasomeExpression of a unique drug-resistant Hsp90 ortholog by the nematode Caenorhabditis elegansThe biochemical role of the heat shock protein 90 chaperone complex in establishing human telomerase activity.The Hsp90 molecular chaperone complex regulates maltose induction and stability of the Saccharomyces MAL gene transcription activator Mal63p.Transgenic overexpression of p23 induces spontaneous hydronephrosis in mice.
P2860
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P2860
Genetic and biochemical analysis of p23 and ansamycin antibiotics in the function of Hsp90-dependent signaling proteins
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Genetic and biochemical analys ...... 0-dependent signaling proteins
@ast
Genetic and biochemical analys ...... 0-dependent signaling proteins
@en
Genetic and biochemical analys ...... 0-dependent signaling proteins
@en-gb
Genetic and biochemical analys ...... 0-dependent signaling proteins
@nl
type
label
Genetic and biochemical analys ...... 0-dependent signaling proteins
@ast
Genetic and biochemical analys ...... 0-dependent signaling proteins
@en
Genetic and biochemical analys ...... 0-dependent signaling proteins
@en-gb
Genetic and biochemical analys ...... 0-dependent signaling proteins
@nl
prefLabel
Genetic and biochemical analys ...... 0-dependent signaling proteins
@ast
Genetic and biochemical analys ...... 0-dependent signaling proteins
@en
Genetic and biochemical analys ...... 0-dependent signaling proteins
@en-gb
Genetic and biochemical analys ...... 0-dependent signaling proteins
@nl
P2860
P356
P1476
Genetic and biochemical analys ...... 0-dependent signaling proteins
@en
P2093
P2860
P304
P356
10.1128/MCB.18.6.3330
P407
P577
1998-06-01T00:00:00Z