Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation
about
Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth.Rb-Raf-1 interaction disruptor RRD-251 induces apoptosis in metastatic melanoma cells and synergizes with dacarbazineRaf family kinases: old dogs have learned new tricksMeaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactionsRb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signalsRING3 kinase transactivates promoters of cell cycle regulatory genes through E2FRaf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanismEndogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathwayTank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis.Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth controlRaf kinases in cancer-roles and therapeutic opportunitiesDisrupting the interaction between retinoblastoma protein and Raf-1 leads to defects in progenitor cell proliferation and survival during early inner ear development.RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development.Overexpression of human Raf-1 enhances radiosensitivity in fission yeast, Schizosaccharomyces pombe.Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.Human Raf-1 proteins associate with Rad24 and Cdc25 in cell-cycle checkpoint pathway of fission yeast, Schizosaccharomyces pombe.Disrupting the Rb-Raf-1 interaction: a potential therapeutic target for cancer.ETS-targeted therapy: can it substitute for MEK inhibitors?Molecular interaction map of the mammalian cell cycle control and DNA repair systems.Natural biology of polyomavirus middle T antigen.BRG1/BRM and prohibitin are required for growth suppression by estrogen antagonists.BRAF mutant non-small cell lung cancer and treatment with BRAF inhibitors.Roles of prohibitin in growth control and tumor suppression in human cancersInhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis.Tangled webs: evidence of cross-talk between c-Raf-1 and Akt.ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumorsNicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways3-Methylcholanthrene, an AhR agonist, caused cell-cycle arrest by histone deacetylation through a RhoA-dependent recruitment of HDAC1 and pRb2 to E2F1 complex.A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude mice.Conferring specificity on the ubiquitous Raf/MEK signalling pathway.Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease.The Mammalian Cell Cycle Regulates Parvovirus Nuclear Capsid Assembly.Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway.Raf kinases: function, regulation and role in human cancer.Activation of the aryl hydrocarbon receptor AhR Promotes retinoic acid-induced differentiation of myeloblastic leukemia cells by restricting expression of the stem cell transcription factor Oct4.Genetic and biochemical alterations in non-small cell lung cancer.PAK1 is a novel MEK-independent raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survivalActivated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner.Requirement for chromatin-remodeling complex in novel tumor suppressor HIC1-mediated transcriptional repression and growth control.Selective disruption of rb-raf-1 kinase interaction inhibits pancreatic adenocarcinoma growth irrespective of gemcitabine sensitivity.
P2860
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P2860
Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Raf-1 physically interacts wit ...... ling and cell cycle regulation
@ast
Raf-1 physically interacts wit ...... ling and cell cycle regulation
@en
Raf-1 physically interacts wit ...... ling and cell cycle regulation
@en-gb
Raf-1 physically interacts wit ...... ling and cell cycle regulation
@nl
type
label
Raf-1 physically interacts wit ...... ling and cell cycle regulation
@ast
Raf-1 physically interacts wit ...... ling and cell cycle regulation
@en
Raf-1 physically interacts wit ...... ling and cell cycle regulation
@en-gb
Raf-1 physically interacts wit ...... ling and cell cycle regulation
@nl
prefLabel
Raf-1 physically interacts wit ...... ling and cell cycle regulation
@ast
Raf-1 physically interacts wit ...... ling and cell cycle regulation
@en
Raf-1 physically interacts wit ...... ling and cell cycle regulation
@en-gb
Raf-1 physically interacts wit ...... ling and cell cycle regulation
@nl
P2093
P2860
P3181
P356
P1476
Raf-1 physically interacts wit ...... ling and cell cycle regulation
@en
P2093
P2860
P304
P3181
P356
10.1128/MCB.18.12.7487
P407
P577
1998-12-01T00:00:00Z