A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
about
Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma.The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts.Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progressionRelationship between contact inhibition and intranuclear S100C of normal human fibroblastsAntitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cellsp38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosisCDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanismsIsolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4Cyclin-binding motifs are essential for the function of p21CIP1Cloning of a differentially expressed I kappa B-related proteinGrowth suppression by p16ink4 requires functional retinoblastoma protein14-3-3 proteins associate with cdc25 phosphatasesRaf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulationModulation of p27(Kip1) levels by the cyclin encoded by Kaposi's sarcoma-associated herpesvirusA dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapyp12(DOC-1) is a novel cyclin-dependent kinase 2-associated proteinArrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcriptionCAK-independent activation of CDK6 by a viral cyclinN-terminal polyubiquitination and degradation of the Arf tumor suppressorConstruction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland developmentRegulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitorsRegulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinaseDisappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat heartsThe ankyrin repeat as molecular architecture for protein recognitionTransforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cellsExtension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressorId2 specifically alters regulation of the cell cycle by tumor suppressor proteinsRegulation of p16CDKN2 expression and its implications for cell immortalization and senescenceIdentification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6Human cyclin E, a nuclear protein essential for the G1-to-S phase transitionCharacterization of a calmodulin kinase II inhibitor protein in brainTumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR dataCell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)Protein p16 as a marker of dysplastic and neoplastic alterations in cervical epithelial cellsA strategy to study tyrosinase transgenes in mouse melanocytes.Mutation analysis of genes that control the G1/S cell cycle in melanoma: TP53, CDKN1A, CDKN2A, and CDKN2BEffect of 5-azacytidine and galectin-1 on growth and differentiation of the human b lymphoma cell line bl36
P2860
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P2860
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
description
1993 nî lūn-bûn
@nan
1993 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
@ast
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
@en
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
@en-gb
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
@nl
type
label
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
@ast
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
@en
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
@en-gb
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
@nl
prefLabel
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
@ast
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
@en
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
@en-gb
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
@nl
P3181
P356
P1433
P1476
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
@en
P2093
P2888
P3181
P356
10.1038/366704A0
P407
P577
1993-12-16T00:00:00Z
P5875
P6179
1015821919