CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production - Test2 - elhamkhani - TriplyDB

CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production

CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production

http://www.wikidata.org/entity/Q24523660

about

Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex Gene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible mice versus cerebral malaria-resistant mice Dealing with the family: CD147 interactions with cyclophilins Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners β-Amyloid: the key peptide in the pathogenesis of Alzheimer's disease Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage APP processing in Alzheimer's disease Complex regulation of γ-secretase: from obligatory to modulatory subunits An Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity Affinity pulldown of γ-secretase and associated proteins from human and rat brain The quiet renaissance of protein nuclear magnetic resonance.Involvement of HAb18G/CD147 in T cell activation and immunological synapse formation.Importance of N-glycosylation on CD147 for its biological functions Targeting CD147 for T to NK Lineage Reprogramming and Tumor Therapy.Cellular distribution of gamma-secretase subunit nicastrin in the developing and adult rat brains.Characterization of an atypical gamma-secretase complex from hematopoietic origin Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease.An interactive network of elastase, secretases, and PAR-2 protein regulates CXCR1 receptor surface expression on neutrophils.Beta-secretase: structure, function, and evolution.γ-Secretase inhibition of murine choroidal neovascularization is associated with reduction of superoxide and proinflammatory cytokines.Identification of novel γ-secretase-associated proteins in detergent-resistant membranes from brain.Dependency of γ-secretase complex activity on the structural integrity of the bilayer.Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta The γ-secretase complex: from structure to function.Transcriptional Regulation of TMP21 by NFAT.Pathological and physiological functions of presenilins.OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin.Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity.Metabotyping of docosahexaenoic acid - treated Alzheimer's disease cell model Nontranscriptional role of Hif-1α in activation of γ-secretase and notch signaling in breast cancer.Micellar extraction possesses a new advantage for the analysis of Alzheimer's disease brain proteome.Solution NMR approaches for establishing specificity of weak heterodimerization of membrane proteins Junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147.Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved.Evaluating Soluble EMMPRIN as a Marker of Disease Activity in Multiple Sclerosis: Studies of Serum and Cerebrospinal Fluid.Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis.CD147 immunoglobulin superfamily receptor function and role in pathology The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation.Aging of the brain, neurotrophin signaling, and Alzheimer's disease: is IGF1-R the common culprit?Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.

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P2860

CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production

http://www.wikidata.org/entity/Q24523660

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2005 nî lūn-bûn

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CD147 is a regulatory subunit ...... myloid beta-peptide production

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CD147 is a regulatory subunit ...... myloid beta-peptide production

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CD147 is a regulatory subunit ...... myloid beta-peptide production

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CD147 is a regulatory subunit ...... myloid beta-peptide production

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CD147 is a regulatory subunit ...... myloid beta-peptide production

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CD147 is a regulatory subunit ...... myloid beta-peptide production

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CD147 is a regulatory subunit ...... myloid beta-peptide production

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CD147 is a regulatory subunit ...... myloid beta-peptide production

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CD147 is a regulatory subunit ...... myloid beta-peptide production

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CD147 is a regulatory subunit ...... myloid beta-peptide production

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Bing K Jap

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Hua Zhou

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Peter J Walian

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Shuxia Zhou

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P2860

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.

Purification and characterization of the human gamma-secretase complex

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Alzheimer's disease: genes, proteins, and therapy

EMMPRIN (CD147), an inducer of matrix metalloproteinase synthesis, also binds interstitial collagenase to the tumor cell surface

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion

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102

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Alzheimer's disease

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