NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain
about
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extensionIdentification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to NckThe JIP group of mitogen-activated protein kinase scaffold proteinsTNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeletonHuman JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factorPSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organizationMolecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral developmentSPAK, a STE20/SPS1-related kinase that activates the p38 pathwayDirect activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeletonCharacterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamilyActivation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRADIdentification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK betaLOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytesMitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinaseA novel GTP-binding protein hGBP3 interacts with NIK/HGKIdentification of Nck family genes, chromosomal localization, expression, and signaling specificityNck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinaseSH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinaseInteraction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase.The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesionNckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bbInteraction between PAK and nck: a template for Nck targets and role of PAK autophosphorylationNck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activationInteraction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinaseNck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathwaysDissecting Nck/Dock signaling pathways in Drosophila visual system.Mechanisms of Hippo pathway regulationAgonistic and antagonistic roles for TNIK and MINK in non-canonical and canonical Wnt signallingIntracellular Theileria annulata promote invasive cell motility through kinase regulation of the host actin cytoskeletonThe yeast centrin, cdc31p, and the interacting protein kinase, Kic1p, are required for cell integrityThe yeast trimeric guanine nucleotide-binding protein alpha subunit, Gpa2p, controls the meiosis-specific kinase Ime2p activity in response to nutrientsCdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.MAP4K4: an emerging therapeutic target in cancerA RING to rule them all? Insights into the Map3k1 PHD motif provide a new mechanistic understanding into the diverse roles of Map3k1Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascadeMEKK1 binds raf-1 and the ERK2 cascade componentsThe Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor
P2860
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P2860
NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain
description
1997 nî lūn-bûn
@nan
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
NIK is a new Ste20-related kin ...... a conserved regulatory domain
@ast
NIK is a new Ste20-related kin ...... a conserved regulatory domain
@en
NIK is a new Ste20-related kin ...... a conserved regulatory domain
@en-gb
NIK is a new Ste20-related kin ...... a conserved regulatory domain
@nl
type
label
NIK is a new Ste20-related kin ...... a conserved regulatory domain
@ast
NIK is a new Ste20-related kin ...... a conserved regulatory domain
@en
NIK is a new Ste20-related kin ...... a conserved regulatory domain
@en-gb
NIK is a new Ste20-related kin ...... a conserved regulatory domain
@nl
prefLabel
NIK is a new Ste20-related kin ...... a conserved regulatory domain
@ast
NIK is a new Ste20-related kin ...... a conserved regulatory domain
@en
NIK is a new Ste20-related kin ...... a conserved regulatory domain
@en-gb
NIK is a new Ste20-related kin ...... a conserved regulatory domain
@nl
P2093
P2860
P3181
P356
P1433
P1476
NIK is a new Ste20-related kin ...... a conserved regulatory domain
@en
P2093
P2860
P304
P3181
P356
10.1093/EMBOJ/16.6.1279
P407
P577
1997-03-01T00:00:00Z