JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension
about
The JIP group of mitogen-activated protein kinase scaffold proteinsJSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathwaySustained JNK1 activation is associated with altered histone H3 methylations in human liver cancerScaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathwayAn antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathwayMip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation.Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factorRegulation of JNK signaling by GSTpIdentification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions.Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activationInteraction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domainAnthrax lethal toxin-mediated killing of human and murine dendritic cells impairs the adaptive immune responseMEK5/ERK5 pathway: the first fifteen yearsSpecificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activationA RING to rule them all? Insights into the Map3k1 PHD motif provide a new mechanistic understanding into the diverse roles of Map3k1MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathwayMEKK1 binds raf-1 and the ERK2 cascade componentsA docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substratesPAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activationRecruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activationA novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathwayMixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components.A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmissionRequirement of the JIP1 scaffold protein for stress-induced JNK activationSubdomain VIII is a specificity-determining region in MEKK1Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathwayIsolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domainA role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closureDeciphering gene expression program of MAP3K1 in mouse eyelid morphogenesisp115 Rho GTPase activating protein interacts with MEKK1.Mitogen-activated protein kinases: specific messages from ubiquitous messengersc-Jun N-terminal kinase contributes to aberrant retinoid signaling in lung cancer cells by phosphorylating and inducing proteasomal degradation of retinoic acid receptor alphaVisualization of JNK activity dynamics with a genetically encoded fluorescent biosensor.Deltex regulates T-cell activation by targeted degradation of active MEKK1.Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants.A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs.A novel mitogen-activated protein kinase is responsive to Raf and mediates growth factor specificity.MEKK3 is essential for lymphopenia-induced T cell proliferation and survival.Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity.
P2860
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P2860
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension
description
1998 nî lūn-bûn
@nan
1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
JNKK1 organizes a MAP kinase m ...... y its amino-terminal extension
@ast
JNKK1 organizes a MAP kinase m ...... y its amino-terminal extension
@en
JNKK1 organizes a MAP kinase m ...... y its amino-terminal extension
@en-gb
JNKK1 organizes a MAP kinase m ...... y its amino-terminal extension
@nl
type
label
JNKK1 organizes a MAP kinase m ...... y its amino-terminal extension
@ast
JNKK1 organizes a MAP kinase m ...... y its amino-terminal extension
@en
JNKK1 organizes a MAP kinase m ...... y its amino-terminal extension
@en-gb
JNKK1 organizes a MAP kinase m ...... y its amino-terminal extension
@nl
prefLabel
JNKK1 organizes a MAP kinase m ...... y its amino-terminal extension
@ast
JNKK1 organizes a MAP kinase m ...... y its amino-terminal extension
@en
JNKK1 organizes a MAP kinase m ...... y its amino-terminal extension
@en-gb
JNKK1 organizes a MAP kinase m ...... y its amino-terminal extension
@nl
P2093
P2860
P356
P1433
P1476
JNKK1 organizes a MAP kinase m ...... y its amino-terminal extension
@en
P2093
P2860
P304
P356
10.1101/GAD.12.21.3369
P407
P50
P577
1998-11-01T00:00:00Z